ReviewAdvances in dental research2012
Clinical evidence for polyol efficacy.
Review in Advances in dental research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Xylitol-containing products for preventing dental caries in children and adults.The Cochrane database of systematic reviews · 2015Pooled it
- Pooled it
- The caries preventive effect of 1-year use of low-dose xylitol chewing gum. A randomized placebo-controlled clinical trial in high-caries-risk adults.Clinical oral investigations · 2017Trial
- Milk Sweetened with Xylitol: A Proof-of-Principle Caries Prevention Randomized Clinical Trial.Journal of dentistry for children (Chicago, Ill.) · 2016Trial
- Long-term effect of maternal xylitol exposure on their children's caries prevalence.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2012Trial
- Comparison of Cariogenic Organic Acid Concentrations According to Combined Use of Sucrose and Sugar Alcohols.Journal of clinical medicine · 2025Article
- Unveiling the impact of allulose on oral microbiota and biofilm formation via a cariogenic potential assessment platform.Frontiers in cellular and infection microbiology · 2025Article
- Effectiveness of New Isomalt-Containing Toothpaste Formulations in Preventing Dental Caries: A Microbial Study.Dentistry journal · 2024Article
- Caries preventing efficacy of new Isomalt-containing mouthrinse formulations: a microbial study.BDJ open · 2024Article
- Resin infiltration in white spot lesions caused by orthodontic hypomineralisation: a minimally invasive therapy.British dental journal · 2021Article
- Potential of Prebiotic D-Tagatose for Prevention of Oral Disease.Frontiers in cellular and infection microbiology · 2021Article
- Rebalancing the Caries Microbiome Dysbiosis: Targeted Treatment and Sugar Alcohols.Advances in dental research · 2018Review
- D‑Tagatose inhibits the growth and biofilm formation of Streptococcus mutans.Molecular medicine reports · 2018Article
- Effects of Xylitol and Sucrose Mint Products on Streptococcus mutans Colonization in a Dental Simulator Model.Current microbiology · 2017Article
- Cariogenicity features of Streptococcus mutans in presence of rubusoside.BMC oral health · 2016Article
- Dietary Research to Reduce Children's Oral Health Disparities: An Exploratory Cross-Sectional Analysis of Socioeconomic Status, Food Insecurity, and Fast-Food Consumption.Journal of the Academy of Nutrition and Dietetics · 2015Article
- Important considerations in the development of toothpaste formulations for children.International dental journal · 2013Review
- Diet and the microbial aetiology of dental caries: new paradigms.International dental journal · 2013Review
- Topical xylitol administration by parents for the promotion of oral health in infants: a caries prevention experiment at a Finnish Public Health Centre.International dental journal · 2013Article
- Prevention and Treatment of White Spot Lesions in Orthodontic Patients.Contemporary clinical dentistryReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
Abstract
Xylitol is a safe dental caries preventive when incorporated into chewing gum or confections used habitually. The goal of this paper is to identify and assess the work on xylitol and other polyols and dental caries since 2008. Xylitol is effective when used by the mother prenatally or after delivery to prevent mutans transmission and subsequent dental caries in the offspring. One new completed trial confirmed that children of mothers who used xylitol lozenges after delivery had less dental caries than a comparison group. A similar study confirmed that the use of xylitol gum by the mother either prevented or postponed MS transmission to the offspring. Xylitol use among schoolchildren delivered via a gummy bear confection reduced S. mutans levels, but a once per day use of xylitol-containing toothpaste did not. Randomized trials, with caries outcomes, assessing xylitol-containing lozenges in adults and xylitol-containing gummy bears in children will release results in the coming year. Other studies are ongoing but are not systematic and will fail to answer important questions about how xylitol, or other polyols, can address the global dental caries problem.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.