ArticleInternational immunology2012
High levels of IL-7 cause dysregulation of thymocyte development.
Article in International immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Revisiting T cells: Innate actions and emerging links to innate memory response.Journal of immunology (Baltimore, Md. : 1950) · 2026Review
- Review
- The Multifaceted Roles of B Cells in the Thymus: From Immune Tolerance to Autoimmunity.Frontiers in immunology · 2021Review
- Thymic B Cells Promote Germinal Center-Like Structures and the Expansion of Follicular Helper T Cells in Lupus-Prone Mice.Frontiers in immunology · 2020Article
- Temporal progression of gene regulation of peripheral white blood cells explains gender dimorphism of critically ill patients after trauma.Molecular medicine (Cambridge, Mass.) · 2019Article
- Interventions to restore appropriate immune function in the elderly.Immunity & ageing : I & A · 2018Review
- Article
- Interleukin-7 in the transition of bone marrow progenitors to the thymus.Immunology and cell biology · 2017Article
- TC-PTP regulates the IL-7 transcriptional response during murine early T cell development.Scientific reports · 2017Article
- Hematopoiesis and T-cell specification as a model developmental system.Immunological reviews · 2016Review
- Article
- Perspectives of the relationship between IL-7 and autoimmune diseases.Clinical rheumatology · 2013Review
- Interleukin-7 receptor controls development and maturation of late stages of thymocyte subpopulations.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
IL-7 signaling is required for thymocyte development and its loss has a severe deleterious effect on thymus function. Thymocyte-stromal cell interactions and other mechanisms tightly regulate IL-7 expression. We show that disruption of that regulation by over-expression of IL-7 inhibits T-cell development and promotes extensive B-cell lymphopoiesis in the thymus. Our data reveal that high levels of IL-7 negate Notch-1 function in thymocytes found in IL-7 transgenic mice and in co-culture with OP9-DL1 cells. While high levels of IL-7R are present on thymocytes, increased suppressor of cytokine signaling-1 expression blunts IL-7 downstream signaling, resulting in hypo-phosphorylation of proteins in the PI3K-Akt pathway. Consequently, GSK3β remains active and inhibits Notch-1 signaling as observed by decreased Hes-1 and Deltex expression in thymic progenitors. This is the first demonstration that high levels of IL-7 antagonize Notch-1 signaling and suggest that IL-7 may affect T- versus B-lineage choice in the thymus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.