ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2012
Mammalian target of rapamycin complex 2 regulates inflammatory response to stress.
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- Covalent modification of nephrilin peptide with valproic acid increases its efficacy as a therapeutic in burn trauma.Burns open : an international open access journal for burn injuries · 2020Article
- Epigenetic memory of oxidative stress: does nephrilin exert its protective effects via Rac1?Biologics : targets & therapy · 2017Article
- Effects of the nephrilin peptide on post-burn glycemic control, renal function, fat and lean body mass, and wound healing.International journal of burns and trauma · 2016Article
- Tribbles homolog 3 attenuates mammalian target of rapamycin complex-2 signaling and inflammation in the diabetic kidney.Journal of the American Society of Nephrology : JASN · 2014Article
- Nephrilin peptide modulates a neuroimmune stress response in rodent models of burn trauma and sepsis.International journal of burns and trauma · 2013Article
- Mammalian tribbles homologs at the crossroads of endoplasmic reticulum stress and Mammalian target of rapamycin pathways.Scientifica · 2013Article
- Positive effects of ferric iron on the systemic efficacy of nephrilin peptide in burn trauma.Scars, burns & healingArticle
- Transcriptional re-programming in rat central nervous system two weeks after burn trauma: the impact of nephrilin treatment on the expression of oxidative stress-related genes.Scars, burns & healingArticle
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
OBJECTIVE AND
designTo explore the role of mammalian target of rapamycin 2 (mTORC2) in the activation of inflammatory and oxidative responses in rodent models of acute injury and metabolic stress. MATERIAL: The impact of nephrilin, an inhibitor of mTORC2 complex, was assessed in three CD-1 mouse models of acute xenobiotic stress and in a hypertensive Dahl rat model of metabolic stress.
methodsAnimals received daily subcutaneous bolus injections of saline or 4 mg/kg nephrilin. Tissues were assayed by ELISA, gene arrays and immunohistochemical staining.
resultsNephrilin significantly inhibited elevations in plasma tumor necrosis factor-alpha, kidney substance P, and CX3CR1, and urinary lipocalin-2 [urinary neutrophil gelatinase-associated lipocalin (uNGAL)] in models of acute xenobiotic stress. UCHL1 gene expression levels dropped and plasma HMGB1 levels rose in the rhabdomyolysis model. Both effects were reversed by nephrilin. The inhibitor also blocked diet-induced elevations of uNGAL and albumin-creatinine ratio (UACR) as well as kidney tissue phosphorylation of PKC-beta-2-T641 and p66shc-S36, and reduced dark ring-like staining of nuclei by anti-phos-p66shc-S36 antibody in frozen sections of diseased kidneys from hypertensive Dahl rats fed an 8 % NaCl diet for 4 weeks.
conclusionsTaken together, our results suggest a role for mTORC2 in the inflammatory-oxidative responses to stress.
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