SynthesisDigestive diseases and sciences2013
Fecal calprotectin in pediatric inflammatory bowel disease: a systematic review.
Synthesis in Digestive diseases and sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Performance of fecal S100A12 as a novel non-invasive diagnostic biomarker for pediatric inflammatory bowel disease: a systematic review and meta-analysis.Jornal de pediatriaPooled it
- Recent Trend of Laboratory Tests in Common Gastrointestinal Tract Disorders.Diagnostics (Basel, Switzerland) · 2025Review
- Cytomegalovirus Detection by PCR on Fresh and Formalin-Fixed Colon Tissue Biopsies of Children with Colitis: A Prospective Cohort Study.Iranian journal of medical sciences · 2025Article
- The use of calgranulin-C (S100A12) and fecal zonulin as possible non-invasive markers in children with inflammatory bowel disease: a clinical study.European journal of pediatrics · 2023Article
- Poor Concordance Between Clinical Activity and Endoscopic Severity in Pediatric Crohn's Disease: Before and After Induction Therapy.Digestive diseases and sciences · 2022Article
- Article
- Comparison of a rapid test and an automated method for faecal calprotectin measurement.Practical laboratory medicine · 2019Article
- Consecutive fecal calprotectin measurements for predicting relapse in pediatric Crohn's disease patients.World journal of gastroenterology · 2019Observational
- Biological effects of interleukin-6 on Gingival Fibroblasts: Cytokine regulation in periodontitis.Journal of cellular physiology · 2018Review
- Autoinhibitory regulation of S100A8/S100A9 alarmin activity locally restricts sterile inflammation.The Journal of clinical investigation · 2018Article
- Practical guidance on the use of faecal calprotectin.Frontline gastroenterology · 2018Review
- Observational
- Article
- Comparison of Fecal Calprotectin Methods for Predicting Relapse of Pediatric Inflammatory Bowel Disease.Canadian journal of gastroenterology & hepatology · 2017Article
- Fecal Calprotectin in Healthy Children Aged 1-4 Years.PloS one · 2016Article
- Disease monitoring in inflammatory bowel disease.World journal of gastroenterology · 2015Review
- Is faecal calprotectin equally useful in all Crohn's disease locations? A prospective, comparative study.Archives of medical science : AMS · 2015Article
- Looking for new treatments of Infantile Colic.Italian journal of pediatrics · 2014Review
- Comparison of three tests for faecal calprotectin in children and young adults: a retrospective monocentric study.BMJ open · 2014Article
- Update in pediatric inflammatory bowel disease.Rheumatic diseases clinics of North America · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInflammatory bowel disease frequently begins during childhood or adolescence. Current tests and procedures for diagnosing and monitoring inflammatory bowel disease are invasive, uncomfortable and costly. Fecal calprotectin is an inflammatory marker tested in several studies including pediatric patients with inflammatory bowel disease.
methodsA search for articles published up to October 2011 was conducted using MEDLINE and EMBASE databases. We included original English-written articles referred to pediatric patients with inflammatory bowel disease and measured fecal calprotectin levels. We extracted data concerning fecal calprotectin levels in patients with inflammatory bowel disease and in the controls groups, sensitivity, specificity, positive and negative likelihood ratio.
resultsThirty-four studies were included. Fecal calprotectin levels of patients with inflammatory bowel disease are much higher than those of healthy controls or patients with functional disorders or other gastrointestinal diseases. The results vary greatly when taking all studies into consideration. Nevertheless, in cases of newly diagnosed and/or active inflammatory bowel disease, the results are more homogeneous, with high sensitivity and positive likelihood ratio, low negative likelihood ratio, but moderate specificity. Moreover, 50 μg/g seems to be the most proper cut-off point for the fecal calprotectin test.
conclusionsThe fecal calprotectin test could be used for supporting diagnosis or confirming relapse of inflammatory bowel disease in pediatric patients. A positive result could confirm the suspicion of either inflammatory bowel disease diagnosis or inflammatory bowel disease relapse, due to the high sensitivity of the test, but a negative result should not exclude these conditions, due to its moderate specificity.
Indexed as
Identifiers
22899243What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.