ReviewDigestive diseases and sciences2013
Clinical utility of 13C-liver-function breath tests for assessment of hepatic function.
Review in Digestive diseases and sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- European guideline on indications, performance and clinical impact ofUnited European gastroenterology journal · 2021Guideline
- Evidence Supporting Utility of the Oral Cholate Challenge Test of Liver Function and Physiology to Aid Clinical Management: A Review of Analytical and Clinical Validation Studies.Gastro hep advances · 2026Review
- Liver Function-How to Screen and to Diagnose: Insights from Personal Experiences, Controlled Clinical Studies and Future Perspectives.Journal of personalized medicine · 2022Review
- Mitochondria Matter: Systemic Aspects of Nonalcoholic Fatty Liver Disease (NAFLD) and Diagnostic Assessment of Liver Function by Stable Isotope Dynamic Breath Tests.International journal of molecular sciences · 2021Review
- Non-Alcoholic Steatohepatitis Decreases Microsomal Liver Function in the Absence of Fibrosis.Biomedicines · 2020Article
- Gd-EOB-DTPA-enhanced T1 relaxometry for assessment of liver function determined by real-timeEuropean radiology · 2018Article
- Hepatobiliary MRI: Signal intensity based assessment of liver function correlated toScientific reports · 2018Article
- Review
- Alternative Sampling Strategies for Cytochrome P450 Phenotyping.Clinical pharmacokinetics · 2016Review
- A profile of volatile organic compounds in exhaled air as a potential non-invasive biomarker for liver cirrhosis.Scientific reports · 2016Article
- Noninvasive assessment of liver function.Current opinion in gastroenterology · 2015Review
- Preoperative liver function assessments to estimate the prognosis and safety of liver resections.Surgery today · 2014Review
- Breath tests to phenotype drug disposition in oncology.Clinical pharmacokinetics · 2013Review
- Relationship between 13C-aminopyrine breath test and the MELD score and its long-term prognostic use in patients with cirrhosis.Digestive diseases and sciences · 2013Article
- How far is the development of 13C-liver-function breath tests?Digestive diseases and sciences · 2013Article
- Phase-1 evaluation of 13C-liver function breath tests.Digestive diseases and sciences · 2013Article
- Assessment of hepatic detoxification activity: proposal of an improved variant of the (13)c-methacetin breath test.PloS one · 2013Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
13C-Liver-function breath tests have been used in clinical diagnostics and, to a limited extent, to investigate hepatic function. From a practical perspective, tests such as the 13C-aminopyrine and 13C-methacetin breath tests are simple to administer, safe, and relatively inexpensive to perform. Surprisingly, they have not entered the mainstream of clinical practice, because they are perceived to lack the specificity and adequate precision needed to give accurate results in real time. The dynamic nature of 13C-liver-function breath tests, their possible versatility in terms of assessing a range of different liver functions, and the ease with which they can be repeated to follow relative changes in liver function with time, all imply the potential for wider clinical application. Therefore, there is a need for these tests to be critically evaluated and their potential clinical application be tested systematically against defined objectives. We describe refinements in the methodology of the tests and propose several situations in which currently reliable methods for assessment of liver function do not exist and where 13C-liver-function breath tests might be of use. We propose that use has been constrained by practical methodological considerations which could be addressed to offer tests better suited to routine application in the out-patient or community setting.
Indexed as
Identifiers
22899241What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.