ArticleBritish journal of cancer2012
Effects of changes in diagnosis and registration on time trends in recorded childhood cancer incidence in Great Britain.
Article in British journal of cancer, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
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- Trends in childhood cancer: Incidence and survival analysis over 45 years of SEER data.PloS one · 2025Article
- Causes of Childhood Cancer: A Review of the Recent Literature: Part I-Childhood Factors.Cancers · 2024Review
- International patterns and trends of childhood and adolescent cancer, 1978-2012.Journal of the National Cancer Center · 2022Article
- Patterns and trends of cancer incidence in children and adolescents in China, 2011-2015: A population-based cancer registry study.Cancer medicine · 2021Article
- Case-control study of paternal occupational exposures and childhood bone tumours and soft-tissue sarcomas in Great Britain, 1962-2010.British journal of cancer · 2020Article
- Childhood cancer incidence and survival trends in Estonia (1970-2016): a nationwide population-based study.BMC cancer · 2020Article
- Incidence of childhood CNS tumours in Britain and variation in rates by definition of malignant behaviour: population-based study.BMC cancer · 2019Article
- Spatial and temporal variations of childhood cancers: Literature review and contribution of the French national registry.Cancer medicine · 2018Review
- Childhood cancer in the UK: achievements and legacy of six decades of research in Oxford.British journal of cancer · 2018Article
- Changing geographical patterns and trends in cancer incidence in children and adolescents in Europe, 1991-2010 (Automated Childhood Cancer Information System): a population-based study.The Lancet. Oncology · 2018Article
- Childhood cancer research in Oxford II: The Childhood Cancer Research Group.British journal of cancer · 2018Article
- Childhood and Adolescence Cancers in the Palermo Province (Southern Italy): Ten Years (2003⁻2012) of Epidemiological Surveillance.International journal of environmental research and public health · 2018Article
- Childhood cancer incidence and survival in Japan and England: A population-based study (1993-2010).Cancer science · 2018Article
- Body size in early life and risk of lymphoid malignancies and histological subtypes in adulthood.International journal of cancer · 2016Article
- Screening for cognitive deficits in 8 to 14-year old children with cerebellar tumors using self-report measures of executive and behavioral functioning and health-related quality of life.Neuro-oncology · 2015Article
- Child-related characteristics predicting subsequent health-related quality of life in 8- to 14-year-old children with and without cerebellar tumors: a prospective longitudinal study.Neuro-oncology practice · 2014Article
- The risk of leukaemia in young children from exposure to tritium and carbon-14 in the discharges of German nuclear power stations and in the fallout from atmospheric nuclear weapons testing.Radiation and environmental biophysics · 2014Article
- Residential distance at birth from overhead high-voltage powerlines: childhood cancer risk in Britain 1962-2008.British journal of cancer · 2014Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundIncreases in recorded childhood cancer incidence are widely reported, but do not necessarily represent real increases in risk. Time trends might conceal underlying steps caused by changes in diagnosis and registration procedures.
methodsUsing records from the National Registry of Childhood Tumours 1966-2005 (N=54650), the age-sex-standardised rate for residents of Great Britain aged under 15 years was calculated by individual year of diagnosis for each cancer subtype, and the average annual percentage change (trend) was assessed. The timing of assumed step changes in rate was estimated by iterative Poisson regression, and compared graphically with the approximate timing of innovations previously identified from published sources.
resultsEstimated timing of underlying steps approximately coincided with the following relevant innovations: biochemical assays, mid-1980s (hepatic and germ-cell cancer); diagnostic imaging, mid-1980s to early 1990s (intracranial/intraspinal tumours, neuroblastoma, soft-tissue sarcoma); revised cancer registration scheme, 1971 (leukaemia, bone and soft-tissue sarcoma); mandatory registration, 1993 (intracranial/intraspinal tumours, retinoblastoma, melanoma/carcinoma); cancer registration improvements, 2001 (leukaemia, renal and hepatic cancer).
conclusionWhile the possibility of some real change in risk cannot be excluded, for many cancer subtypes the estimated timing of underlying step changes in rate appeared to correspond with changes in diagnosis or registration procedures. Childhood cancer may have been considerably under-recorded in the past.
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