Trial reportDiabetologia2012
Marked resistance of femoral adipose tissue blood flow and lipolysis to adrenaline in vivo.
Trial report in Diabetologia, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 47 citations in OpenAlex.
- Glucocorticoids modulate human brown adipose tissue thermogenesis in vivo.Metabolism: clinical and experimental · 2017Trial
- Acute Hypercortisolemia Exerts Depot-Specific Effects on Abdominal and Femoral Adipose Tissue Function.The Journal of clinical endocrinology and metabolism · 2017Trial
- Impaired Mitochondrial Respiration in Upper Compared to Lower Body Differentiated Human Adipocytes and Adipose Tissue.The Journal of clinical endocrinology and metabolism · 2024Article
- Independent relevance of adiposity measures to coronary heart disease risk among 0.5 million adults in UK Biobank.International journal of epidemiology · 2023Article
- The associations between body fat distribution and bone mineral density in the Oxford Biobank: a cross sectional study.Expert review of endocrinology & metabolism · 2022Article
- Oxygenation of adipose tissue: A human perspective.Acta physiologica (Oxford, England) · 2020Review
- Bone morphogenetic protein 2 is a depot-specific regulator of human adipogenesis.International journal of obesity (2005) · 2019Article
- In-vivo metabolic studies of regional adipose tissue.Cardiovascular endocrinology & metabolism · 2018Review
- Cohort Profile: The Oxford Biobank.International journal of epidemiology · 2018Article
- Ectopic Fat Accumulation in Distinct Insulin Resistant Phenotypes; Targets for Personalized Nutritional Interventions.Frontiers in nutrition · 2018Review
- Glucagon-like peptide-1 elicits vasodilation in adipose tissue and skeletal muscle in healthy men.Physiological reports · 2017Article
- Article
- The Physiological Regulation of Skeletal Muscle Fatty Acid Supply and Oxidation During Moderate-Intensity Exercise.Sports medicine (Auckland, N.Z.) · 2015Review
- Adipose tissue and metabolic syndrome: too much, too little or neither.European journal of clinical investigation · 2015Review
- Subcutaneous fat transplantation alleviates diet-induced glucose intolerance and inflammation in mice.Diabetologia · 2015Article
- Biology of upper-body and lower-body adipose tissue--link to whole-body phenotypes.Nature reviews. Endocrinology · 2015Review
- Opportunities for intervention strategies for weight management: global actions on fluid intake patterns.Obesity facts · 2015Review
- Regulation of human subcutaneous adipose tissue blood flow.International journal of obesity (2005) · 2014Review
- The role of adipose tissue in insulin resistance in women of African ancestry.Journal of obesity · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
aims/hypothesisFatty acid entrapment in femoral adipose tissue has been proposed to prevent ectopic fat deposition and visceral fat accumulation, resulting in protection from insulin resistance. Our objective was to test the hypothesis of femoral, compared with abdominal, adipose tissue resistance to adrenergic stimulation in vivo as a possible mechanism.
methodsRegional fatty acid trafficking, along with the measurement of adipose tissue blood flow (ATBF) with (133)Xe washout, was studied with the arteriovenous difference technique and stable isotope tracers in healthy volunteers. Adrenergic agonists (isoprenaline, adrenaline [epinephrine]) were infused either locally by microinfusion or systemically. Local microinfusion of adrenoceptor antagonists (propranolol, phentolamine) was used to characterise specific adrenoceptor subtype effects in vivo.
resultsFemoral adipose tissue NEFA release and ATBF were lower during adrenaline stimulation than in abdominal tissue (p < 0.001). Mechanistically, femoral adipose tissue displayed a dominant α-adrenergic response during adrenaline stimulation. The α-adrenoceptor blocker, phentolamine, resulted in the 'disinhibition' of the femoral ATBF response to adrenaline (p < 0.001). CONCLUSIONS/
interpretationFatty acids, once stored in femoral adipose tissue, are not readily released upon adrenergic stimulation. Femoral adipose tissue resistance to adrenaline may contribute to the prevention of ectopic fatty acid deposition.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.