Evidence map›Paper›PMID 22898716›Full record

Trial reportEuropean journal of applied physiology2013

Resistance training induced increase in muscle fiber size in young and older men.

A A Mero, J J Hulmi, H Salmijärvi, M Katajavuori, M Haverinen, J Holviala, T Ridanpää, K Häkkinen, V Kovanen, J P Ahtiainen and 1 more

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of applied physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 5 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 5 syntheses or guidelines pooled it, 81 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
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  11. Article
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  13. Review
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  15. Review
  16. Effects of functional training with blood occlusion on the irisin, follistatin, and myostatin myokines in elderly men.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2022
    Article
  17. Stubborn Exercise Responders-Where to Next?Sports (Basel, Switzerland) · 2022
    Review
  18. Myokines and Resistance Training: A Narrative Review.International journal of molecular sciences · 2022
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

A A MeroDepartment of Biology of Physical Activity and Neuromuscular Research Center, University of Jyväskylä, PO Box 35, 40351 Jyväskylä, Finland. antti.a.mero@jyu.fi
J J Hulmi
H Salmijärvi
M Katajavuori
M Haverinen
J Holviala
T Ridanpää
K Häkkinen
V Kovanen
J P Ahtiainen
H Selänne
University of Jyväskylä · FICentral Finland Health Care District · FILIKES – Foundation for Sport and Health Sciences · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Muscle strength and mass decline in sedentary individuals with aging. The present study investigated the effects of both age and 21 weeks of progressive hypertrophic resistance training (RT) on skeletal muscle size and strength, and on myostatin and myogenin mRNA expression in 21 previously untrained young men (26.0 ± 4.3 years) and 18 older men (61.2 ± 4.1 years) and age-matched controls. Vastus lateralis muscle biopsies were taken before and after RT. Type I and type II muscle fiber cross-sectional areas increased more in young men than in older men after RT (P < 0.05). Concentric leg extension increased (P < 0.05) more after 10.5 weeks in young men compared to older men, but after 21 weeks no statistical differences existed. The daily energy and protein intake were greater (P < 0.001) in young subjects. Both myostatin and myogenin mRNA expression increased in older when compared with young men after RT (P < 0.05). In conclusion, after RT, muscle fiber size increased less in older compared to young men. This was associated with lower protein and energy intake and increases in myostatin gene expression in older when compared to young men.

Indexed as

Resistance TrainingAdultAgedAge FactorsAgingHumansMaleMiddle AgedMuscle Fibers, SkeletalMuscle StrengthNutritional Physiological PhenomenaRNA, MessengerYoung AdultRNA, Messenger

Identifiers

PMID22898716
OpenAlexW1973793244

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.