ArticleBehavioural brain research2012
Neural and behavioral responses to low-grade inflammation.
Article in Behavioural brain research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
28 citing papers in PubMed, 48 citations in OpenAlex.
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- The inflammatory response to birth requires MyD88 and is driven by both mother and offspring.Brain, behavior, and immunity · 2024Article
- Ovariectomy in mice primes hippocampal microglia to exacerbate behavioral sickness responses.Brain, behavior, & immunity - health · 2023Article
- Elevated Systemic Levels of Markers Reflecting Intestinal Barrier Dysfunction and Inflammasome Activation Are Correlated in Severe Mental Illness.Schizophrenia bulletin · 2023Article
- Liposaccharide-induced sustained mild inflammation fragments social behavior and alters basolateral amygdala activity.Psychopharmacology · 2023Article
- GSK3β Inhibition by Phosphorylation at SerInternational journal of molecular sciences · 2022Article
- Ovarian status modulates endocrine and neuroinflammatory responses to a murine mammary tumor.American journal of physiology. Regulatory, integrative and comparative physiology · 2022Article
- Low-dose lipopolysaccharide as an immune regulator for homeostasis maintenance in the central nervous system through transformation to neuroprotective microglia.Neural regeneration research · 2021Review
- Article
- Lipopolysaccharide-induced inflammation leads to acute elevations in pro-inflammatory cytokine expression in a mouse model of Fragile X syndrome.Physiology & behavior · 2020Article
- Immunomodulatory T cell death associated gene-8 (TDAG8) receptor in depression-associated behaviors.Physiology & behavior · 2019Article
- Review on Cross Talk between Neurotransmitters and Neuroinflammation in Striatum and Cerebellum in the Mediation of Motor Behaviour.BioMed research international · 2019Review
- 11β-hydroxysteroid dehydrogenase-1 deficiency alters brain energy metabolism in acute systemic inflammation.Brain, behavior, and immunity · 2018Article
- Protective effect of aspirin treatment on mouse behavior in the acute phase of experimental infection with Trypanosoma cruzi.Parasitology research · 2018Article
- Physical versus psychological social stress in male rats reveals distinct cardiovascular, inflammatory and behavioral consequences.PloS one · 2017Article
- Pathogen-Host Defense in the Evolution of Depression: Insights into Epidemiology, Genetics, Bioregional Differences and Female Preponderance.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Review
- Repeated LPS Injection Induces Distinct Changes in the Kynurenine Pathway in Mice.Neurochemical research · 2016Article
- A potential role for the acid-sensing T cell death associated gene-8 (TDAG8) receptor in depression-like behavior.Physiology & behavior · 2015Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Neural and behavioral responses after peripheral immune challenge have been observed in numerous studies. The majority of these studies have utilized relatively high doses of lipopolysaccharide (LPS) as the immune stimulant. Little attention has been given to the effects of LPS dose ranges that simulate low grade-inflammation. The current studies were designed to characterize neural and behavioral responses following low-dose LPS stimulation. Results show burrowing and open field activity was significantly impaired following a single i.p. injection of 10, but not 1, μg/kg of LPS. In addition, following repeated 1 μg/kg LPS administration for 10 days, animals showed the progressive development of motor deficits over time. To correlate behavior with CNS activity, cFos activation was determined in the paraventricular nucleus, nucleus of the solitary tract, central amygdaloid nucleus, and ventrolateral medulla. Data revealed there was a dose-dependent activation in all brain areas examined, but only the PVN showed significant activation by low-dose LPS. Additionally, animals that received 1 μg/kg of LPS for 8 days had PVN cFos activation similar to animals that received a single 10 μg/kg LPS injection. These data demonstrate neural and behavior responses can be induced by low-grade inflammation and chronic exposure to sub-threshold levels of LPS can precipitate significantly heightened neural and behavioral responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.