ArticlePlant physiology2012
LONO1 encoding a nucleoporin is required for embryogenesis and seed viability in Arabidopsis.
Article in Plant physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- The role of phase separation for RNA and protein transport through the nuclear pore complex.Journal of experimental botany · 2026Review
- Nucleoporin PNET1 coordinates mitotic nuclear pore complex dynamics for rapid cell division.Nature plants · 2025Article
- Genome-Wide Association Study Identifies a Rice Panicle Blast Resistance GeneInternational journal of molecular sciences · 2022Article
- Function of Nuclear Pore Complexes in Regulation of Plant Defense Signaling.International journal of molecular sciences · 2022Review
- Nucleocytoplasmic Communication in Healthy and Diseased Plant Tissues.Frontiers in plant science · 2021Review
- Nucleoporin Nup98 participates in flowering regulation in a CONSTANS-independent mode.Plant cell reports · 2019Article
- The nuclear pore proteins Nup88/214 and T-cell acute lymphatic leukemia-associated NUP214 fusion proteins regulate Notch signaling.The Journal of biological chemistry · 2019Article
- Decreased Expression of a Gene Caused by a T-DNA Insertion in an Adjacent Gene in Arabidopsis.PloS one · 2016Article
- InsP6-sensitive variants of the Gle1 mRNA export factor rescue growth and fertility defects of the ipk1 low-phytic-acid mutation in Arabidopsis.The Plant cell · 2015Article
- Nucleoporin MOS7/Nup88 is required for mitosis in gametogenesis and seed development in Arabidopsis.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Components of the Arabidopsis nuclear pore complex play multiple diverse roles in control of plant growth.Journal of experimental botany · 2014Article
- Functional insights of nucleocytoplasmic transport in plants.Frontiers in plant science · 2014Review
- Insights into mRNA export-linked molecular mechanisms of human disease through a Gle1 structure-function analysis.Advances in biological regulation · 2014Review
- HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENES1 is required for circadian periodicity through the promotion of nucleo-cytoplasmic mRNA export in Arabidopsis.The Plant cell · 2013Article
- Identification and analysis of LNO1-like and AtGLE1-like nucleoporins in plants.Plant signaling & behavior · 2013Article
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Authors and funding
3 authors at 1 institution in 1 country.
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Abstract
Early embryogenesis in Arabidopsis (Arabidopsis thaliana) is distinguished by a predictable pattern of cell divisions and is a good system for investigating mechanisms of developmental pattern formation. Here, we identified a gene called LONO1 (LNO1) in Arabidopsis in which mutations can abolish the first asymmetrical cell division of the zygote, alter planes and number of cell divisions in early embryogenesis, and eventually arrest embryo development. LNO1 is highly expressed in anthers of flower buds, stigma papilla of open flowers, and embryo and endosperm during early embryogenesis, which is correlated with its functions in reproductive development. The homozygous lno1-1 seed is not viable. LNO1, a homolog of the nucleoporin NUP214 in human (Homo sapiens) and Nup159 in yeast (Saccharomyces cerevisiae), encodes a nucleoporin protein containing phenylalanine-glycine repeats in Arabidopsis. We demonstrate that LNO1 can functionally complement the defect in the yeast temperature-sensitive nucleoporin mutant nup159. We show that LNO1 specifically interacts with the Arabidopsis DEAD-box helicase/ATPase LOS4 in the yeast two-hybrid assay. Furthermore, mutations in AtGLE1, an Arabidopsis homolog of the yeast Gle1 involved in the same poly(A) mRNA export pathway as Nup159, also result in seed abortion. Our results suggest that LNO1 is a component of the nuclear pore complex required for mature mRNA export from the nucleus to the cytoplasm, which makes LNO1 essential for embryogenesis and seed viability in Arabidopsis.
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