Trial reportGastrointestinal endoscopy2012
A prospective comparative study of optical coherence tomography and EUS for tumor staging of superficial esophageal squamous cell carcinoma.
Trial report in Gastrointestinal endoscopy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The clinical usefulness of optical coherence tomography during cancer interventions.Journal of cancer research and clinical oncology · 2018Pooled it
- Current status and perspectives of esophageal cancer: a comprehensive review.Cancer communications (London, England) · 2025Review
- Differential diagnosis of acute and chronic colitis in mice by optical coherence tomography.Quantitative imaging in medicine and surgery · 2022Article
- Advanced endoscopic imaging for detecting and guiding therapy of early neoplasias of the esophagus.Annals of the New York Academy of Sciences · 2020Review
- Staging of T1 esophageal adenocarcinoma with volumetric laser endomicroscopy: a feasibility study.Endoscopy international open · 2019Article
- Feasibility of using optical coherence tomography to detect radiation-induced fibrosis and residual cancer extent after neoadjuvant chemo-radiation therapy: an ex vivo study.Biomedical optics express · 2018Article
- Use of volumetric laser endomicroscopy for determining candidates for endoscopic therapy in superficial esophageal squamous cell carcinoma.United European gastroenterology journal · 2018Article
- The in vivo tissue effect of endoscopic balloon-based radiofrequency ablation in treating esophageal squamous cell neoplasia.United European gastroenterology journal · 2018Article
- Endoscopic diagnosis and treatment of early esophageal squamous neoplasia.World journal of gastrointestinal endoscopy · 2017Review
- Endoscopic optical coherence tomography: technologies and clinical applications [Invited].Biomedical optics express · 2017Article
- Evaluation of preoperative staging for esophageal squamous cell carcinoma.World journal of gastroenterology · 2016Review
- Predictors for postoperative esophageal stricture after balloon-based radiofrequency ablation for early esophageal squamous neoplasia: a multicenter validation study.Therapeutic advances in gastroenterology · 2016Article
- Recent development of optical coherence tomography for preoperative diagnosis of esophageal malignancies.World journal of gastrointestinal endoscopy · 2015Review
- Advances in upper gastrointestinal endoscopy.F1000Research · 2015Review
- Expanding Functionality of Commercial Optical Coherence Tomography Systems by Integrating a Custom Endoscope.PloS one · 2015Article
- Endoscopic mucosal imaging of gastrointestinal neoplasia in 2013.Current gastroenterology reports · 2013Review
- Screening for precancerous lesions of upper gastrointestinal tract: from the endoscopists' viewpoint.Gastroenterology research and practice · 2013Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe precise assessment of superficial esophageal squamous cell carcinomas (SESCCs) limited to the epithelium (EP) or lamina propria mucosa (LPM), the standard indication for endoscopic resection, is important to ensure good outcomes of endoscopic resection. With regard to tomographic imaging techniques, although the accuracy of EUS is practically insufficient, we previously demonstrated that high-resolution optical coherence tomography (OCT) might enable precise assessment for staging in a noninvasive and real-time manner.
objectiveTo clarify the accuracy of the preoperative staging of SESCCs by using OCT compared with that by using 20-MHz probe-type EUS.
designA prospective study.
settingAn academic medical center. PATIENTS: A total of 123 consecutive patients with 131 SESCCs were enrolled from May 2007 to September 2011.
interventionsA specialist examined the patients, by using both OCT and EUS, recorded a representative still image for each lesion, and reported the staging immediately after each examination. Another blinded investigator reviewed the recorded images and reported the staging independently. The histological staging was confirmed by the resected specimens. Finally, we calculated the accuracy of staging by using OCT and EUS. MAIN OUTCOME MEASUREMENTS: The accuracy of OCT or EUS for EP/LPM.
resultThe accuracy for EP/LPM by using OCT was significantly higher than that by using EUS (OCT, 94.6%; HF-EUS, 80.6%; P < .05). Interobserver agreement of OCT and EUS was good and moderate, respectively. LIMITATIONS: The small number of patients; a single-center, single-operator, nonrandomized, crossover study.
conclusionsWe prospectively demonstrated that the preoperative staging of SESCC by using OCT was more useful than that by using EUS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.