ArticleAnnals of intensive care2012
The transition from acute to chronic pain: might intensive care unit patients be at risk?
Article in Annals of intensive care, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 84 citations in OpenAlex.
- Paramedic analgesia comparing ketamine and morphine in trauma. A synopsis of the PACKMaN double-blind RCT.Health technology assessment (Winchester, England) · 2026Trial
- Incidence and Associated Factors for Chronic Pain After ICU Discharge: A Prospective Study.Nursing in critical care · 2026Article
- Cost-effectiveness of paramedic administered ketamine compared to morphine for the management of acute severe pain from traumatic injury.Cost effectiveness and resource allocation : C/E · 2026Article
- Towards a better definition of nociplastic pain conditions: a psychological grounded study on fibromyalgia, chronic headache and vulvodynia.European journal of psychotraumatology · 2025Article
- Opioid Administration in Complex Ventilated Patients in a Surgical Intensive Care Unit.The Journal of surgical research · 2025Observational
- Randomised controlled trial of analgesia for the management of acute severe pain from traumatic injury: study protocol for the paramedic analgesia comparing ketamine and morphine in trauma (PACKMaN).Scandinavian journal of trauma, resuscitation and emergency medicine · 2023Article
- Adverse Effects of Repeated, Intravenous Morphine on Recovery after Spinal Cord Injury in Young, Male Rats Are Blocked by a Kappa Opioid Receptor Antagonist.Journal of neurotrauma · 2022Article
- Morphine-induced changes in the function of microglia and macrophages after acute spinal cord injury.BMC neuroscience · 2022Article
- Pain assessment and analgesic management in patients admitted to intensive care: an Australian and New Zealand point prevalence study.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2022Article
- Pain, Anxiety, and the Continuous Use of Opioids and Benzodiazepines in Trauma Intensive Care Unit Survivors: An Exploratory Study.Puerto Rico health sciences journal · 2022Article
- Depressive and Anxiety Symptoms in Severe COVID-19 Survivors: A Prospective Cohort Study.The Psychiatric quarterly · 2022Article
- The first 24 h: opioid administration in people with spinal cord injury and neurologic recovery.Spinal cord · 2020Article
- Microglia: A Potential Therapeutic Target for Sepsis-Associated Encephalopathy and Sepsis-Associated Chronic Pain.Frontiers in pharmacology · 2020Review
- Sedation strategies in children with pediatric acute respiratory distress syndrome (PARDS).Annals of translational medicine · 2019Review
- Chronic pain in critical care survivors: a narrative review.British journal of anaesthesia · 2019Review
- Care of ICU survivors in the community: a guide for GPs.The British journal of general practice : the journal of the Royal College of General Practitioners · 2017Article
- Neurobiological Effects of Morphine after Spinal Cord Injury.Journal of neurotrauma · 2017Article
- Resilience in Survivors of Critical Illness in the Context of the Survivors' Experience and Recovery.Annals of the American Thoracic Society · 2016Article
- Dependence of Nociceptive Detection Thresholds on Physiological Parameters and Capsaicin-Induced Neuroplasticity: A Computational Study.Frontiers in computational neuroscience · 2016Article
- Chronic pain in survivors of critical illness: a retrospective analysis of incidence and risk factors.Critical care (London, England) · 2013Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pain remains a significant problem for patients hospitalized in intensive care units (ICUs). As research has shown, for some of these patients pain might even persist after discharge and become chronic. Exposure to intense pain and stress during medical and nursing procedures could be a risk factor that contributes to the transition from acute to chronic pain, which is a major disruption of the pain neurological system. New evidence suggests that physiological alterations contributing to chronic pain states take place both in the peripheral and central nervous systems. The purpose of this paper is to: 1) review cutting-edge theories regarding pain and mechanisms that underlie the transition from acute to chronic pain, such as increases in membrane excitability of peripheral and central nerve fibers, synaptic plasticity, and loss of the function of descending inhibitory pain fibers; 2) provide information on the association between the immune system and pain and its crucial contribution to development of chronic pain syndromes, and 3) discuss mechanisms at brain levels in the nervous system and their contribution to affective (i.e., emotional) states associated with chronic pain conditions. Finally, we will offer suggestions for ICU clinical interventions to attempt to prevent the transition from acute to chronic pain.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.