ArticleBiology of sex differences2012
Sex differences in HDL ApoC-III in American Indian youth.
Article in Biology of sex differences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors at 3 institutions in 1 country.
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Abstract
unlabelled
backgroundSince American Indians are predisposed to type 2 diabetes (DM2) and associated cardiovascular risk, Cherokee boys and girls (n = 917) were studied to determine whether BMI Z (body mass index Z score) is associated with the apoC-III (apolipoprotein C-III) content of HDL (high density lipoprotein), a previously reported predictor of DM2.
methodsAn ad hoc cross-sectional analysis was conducted on a previously studied cohort. Participants were grouped by gender-specific age groups (5 to 9, 10 to 14 and 15 to 19 years). ApoA-I (apolipoprotein A-I) and HDL apoC-III were assayed by electroimmunoassay. ApoC-III was measured in whole plasma, and in HDL to determine the molar proportion to apoA-I. General linear models were used to assess association.
resultsThe HDL apoC-III to apoA-I molar ratio increased by BMI Z quartile in girls aged 10-14 years (p < 0.05 for linear trend, p < 0.05 for difference in BMI Z quartile IV vs. I to III) and aged 15-19 years (p < 0.05 for trend). In boys the increase by BMI Z occurred only at ages 15-19 years (p < 0.01 for trend and for quartile difference).
conclusionsApoC-III showed an obesity-related increase relative to apoA-I during adolescence beginning in girls aged 10 to 14 years and in boys aged 15 to 19 years. The earlier changes in girls may alter HDL's protective properties on the β-cell and contribute to their increased risk for DM2.
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