ArticleJACC. Cardiovascular imaging2012
Associations of LV hypertrophy with prevalent and incident valve calcification: Multi-Ethnic Study of Atherosclerosis.
Article in JACC. Cardiovascular imaging, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 42 citations in OpenAlex.
- Mitral annular calcification: implications on clinical outcomes and interventions.Annals of cardiothoracic surgery · 2025Review
- Mitral Annular Calcification: Understanding the Disease and Treatment Options.Structural heart : the journal of the Heart Team · 2025Review
- Differences in risk factors associated with the initiation and progression of mitral annular calcification in asymptomatic individuals.Scientific reports · 2025Article
- Aortic Valve Sclerosis and Degenerative Valve Disease in a Nigerian Population: An Echocardiographic Study.Global heart · 2025Article
- Prognostic value of mitral annular calcification in coronary atherosclerotic disease assessed by coronary computed tomographic angiography.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2024Article
- Higher serum phosphate within the normal range is associated with the development of calcified aortic valve disease.Frontiers in cardiovascular medicine · 2024Article
- Left ventricular outflow tract obstruction after transcatheter mitral valve replacement: a case report with a multifaceted approach.Frontiers in cardiovascular medicine · 2024Article
- Risk Factors and Outcomes With Progressive Mitral Annular Calcification.Journal of the American Heart Association · 2023Article
- Impact of Aortic Valve Regurgitation on Doppler Echocardiographic Parameters in Patients with Severe Aortic Valve Stenosis.Diagnostics (Basel, Switzerland) · 2023Article
- Aortic Valve Calcium in Relation to Subclinical Cardiac Dysfunction and Risk of Heart Failure.Circulation. Cardiovascular imaging · 2023Article
- Unlocking the Secrets of Subclinical Calcific Aortic Valve Disease and Heart Failure.Circulation. Cardiovascular imaging · 2023Article
- Mitral Annular Calcification and Calcific Mitral Stenosis: Therapeutic Challenges and Considerations.Current treatment options in cardiovascular medicine · 2019Review
- Relationship between cardiac calcification and left ventricular hypertrophy in patients with chronic kidney disease at hemodialysis initiation.Heart and vessels · 2017Article
- Associations between hip bone mineral density, aortic calcification and cardiac workload in community-dwelling older Australians.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Article
- Correlation between Subclinical Heart Disease and Cardiovascular Risk Profiles in an Urban Emergency Department Population with Elevated Blood Pressures: A Pilot Study.The Journal of emergency medicine · 2015Article
- Difference in left ventricular mass index between hypertensive patients with and without renal artery stenosis by propensity score analysis.Journal of clinical hypertension (Greenwich, Conn.) · 2014Article
- Coronary artery calcification in chronic kidney disease: An update.World journal of cardiology · 2014Review
- Clinical and Hemodynamic Implications of Mitral Annular Calcification.Journal of the Heart Valve SocietyArticle
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Authors and funding
8 authors at 7 institutions in 2 countries.
Funding
Abstract
objectivesThe aim of this study was to evaluate the relationship between percentage of predicted left ventricular mass (%PredLVM) and valve calcification in the MESA (Multi-Ethnic Study of Atherosclerosis) study.
backgroundCardiac valve calcification has been associated with left ventricular hypertrophy (LVH), which portends cardiovascular events. However, this relationship and its mediators are poorly understood.
methodsThe MESA study is a longitudinal cohort study of men and women 45 to 84 years of age without clinical cardiovascular disease in whom serial cardiac magnetic resonance and computed tomography imaging were performed. The relationships between baseline %PredLVM and the prevalence, severity, and incidence of aortic valve (AVC) and mitral annulus calcification (MAC) were determined by regression modeling.
resultsPrevalent AVC was observed in 630, and MAC was observed in 442 of 5,042 subjects (median 55.9 and 71.1 Agatston units, respectively). After adjustment for age, sex, body mass index (BMI), ethnicity, socioeconomic status, physical activity, diabetes, cholesterol levels, blood pressure, smoking, kidney function, serum lipids, and antihypertensive and statin medications, %PredLVM was associated with prevalent AVC (odds ratio [OR]: 1.18/SD increase in %PredLVM [95% confidence interval (CI): 1.08 to 1.30]; p = 0.0004) and MAC (OR: 1.18 [95% CI: 1.06 to 1.32]; p = 0.002). Similarly, %PredLVM was associated with increased severity of prevalent AVC (risk difference = 0.26 [95% CI: 0.15 to 0.38]; p < 0.0001) and MAC (risk difference = 0.20 [95% CI: 0.03 to 0.37]; p = 0.02). During follow-up (mean 2.4 ± 0.9 years), 153 subjects (4%) developed AVC, and 198 (5%) developed MAC. The %PredLVM was associated with incident AVC (OR: 1.24 [95% CI: 1.04 to 1.47]; p = 0.02) and MAC (OR: 1.18 [95% CI: 1.01 to 1.40]; p = 0.04). Further adjustment for inflammatory markers and coronary artery calcification did not attenuate these associations. Specifically, concentric LVH most strongly predicted incident valve calcification.
conclusionsWithin the MESA cohort, LVH was associated with prevalence, severity, and incidence of valve calcification independent of hypertension and other identified confounders.
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