ArticleJournal of proteome research2012
Rat mammary extracellular matrix composition and response to ibuprofen treatment during postpartum involution by differential GeLC-MS/MS analysis.
Article in Journal of proteome research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 37 citations in OpenAlex.
- Postpartum breast cancer as a distinct oncologic entity: linking physiological tissue remodelling to tumor biology and clinical translation.Breast cancer research : BCR · 2026Review
- Status of breast cancer detection in young women and potential of liquid biopsy.Frontiers in oncology · 2024Review
- The Role of Extracellular Matrix Proteins in Breast Cancer.Journal of clinical medicine · 2022Review
- Combining Immune-Related Genes For Delineating the Extracellular Matrix and Predicting Hormone Therapy and Neoadjuvant Chemotherapy Benefits In Breast Cancer.Frontiers in immunology · 2022Article
- Inflammation, immunity, and vascular remodeling in pulmonary hypertension; Evidence for complement involvement?Global cardiology science & practice · 2020Review
- Role of lineage-specific matrix in stem cell chondrogenesis.Biomaterials · 2020Article
- The Mammary Tumor Microenvironment.Advances in experimental medicine and biology · 2020Article
- 3D bioprinted mammary organoids and tumoroids in human mammary derived ECM hydrogels.Acta biomaterialia · 2019Article
- Ibuprofen supports macrophage differentiation, T cell recruitment, and tumor suppression in a model of postpartum breast cancer.Journal for immunotherapy of cancer · 2018Article
- Porcine Breast Extracellular Matrix Hydrogel for Spatial Tissue Culture.International journal of molecular sciences · 2018Article
- Targeted matrisome analysis identifies thrombospondin-2 and tenascin-C in aligned collagen stroma from invasive breast carcinoma.Scientific reports · 2018Article
- Mucosal Immunity in the Female Murine Mammary Gland.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Article
- Mammary Gland Involution Provides a Unique Model to Study the TGF-β Cancer Paradox.Journal of clinical medicine · 2017Review
- Quantitative extracellular matrix proteomics to study mammary and liver tissue microenvironments.The international journal of biochemistry & cell biology · 2016Article
- Comparative proteomic assessment of matrisome enrichment methodologies.The Biochemical journal · 2016Article
- Raised mammographic density: causative mechanisms and biological consequences.Breast cancer research : BCR · 2016Review
- Increased peri-ductal collagen micro-organization may contribute to raised mammographic density.Breast cancer research : BCR · 2016Article
- Quantification of extracellular matrix proteins from a rat lung scaffold to provide a molecular readout for tissue engineering.Molecular & cellular proteomics : MCP · 2015Article
- Capturing relevant extracellular matrices for investigating cell migration.F1000Research · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Breast cancer patients diagnosed within five years following pregnancy have increased metastasis and decreased survival. A hallmark of postpartum biology that may contribute to this poor prognosis is mammary gland involution, involving massive epithelial cell death and dramatic stromal remodeling. Previous studies show pro-tumorigenic properties of extracellular matrix (ECM) isolated from rodent mammary glands undergoing postpartum involution. More recent work demonstrates systemic ibuprofen treatment during involution decreases its tumor-promotional nature. Utilizing a proteomics approach, we identified relative differences in the composition of mammary ECM isolated from nulliparous rats and those undergoing postpartum involution, with and without ibuprofen treatment. GeLC-MS/MS experiments resulted in 20327 peptide identifications that mapped to 884 proteins with a <0.02% false discovery rate. Label-free quantification yielded several ECM differences between nulliparous and involuting glands related to collagen-fiber organization, cell motility and attachment, and cytokine regulation. Increases in known pro-tumorigenic ECM proteins osteopontin, tenascin-C, and laminin-α1 and pro-inflammatory proteins STAT3 and CD68 further identify candidate mediators of breast cancer progression specific to the involution window. With postpartum ibuprofen treatment, decreases in tenascin-C and three laminin chains were revealed. Our data suggest novel ECM mediators of breast cancer progression and demonstrate a protective influence of ibuprofen on mammary ECM composition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.