ArticleBritish journal of clinical pharmacology2013
Effects of preconceptional paternal drug exposure on birth outcomes: cohort study of 340 000 pregnancies using Norwegian population-based databases.
Article in British journal of clinical pharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- British Society for Rheumatology guideline on prescribing drugs in pregnancy and breastfeeding: immunomodulatory anti-rheumatic drugs and corticosteroids.Rheumatology (Oxford, England) · 2023Guideline
- The effect of paternal exposure to immunosuppressive drugs on sexual function, reproductive hormones, fertility, pregnancy and offspring outcomes: a systematic review.Human reproduction update · 2020Pooled it
- Limitations of FAERS-based analyses of paternal drug exposure: The critical need for maternal data integration.Andrology · 2026Article
- The influence of paternal preconception health on birth defects and head circumference: A scoping review.PLOS global public health · 2026Article
- The influence of paternal preconception health on infant birth weight: A scoping review.PloS one · 2026Article
- Paternal Valproate Use and Neurodevelopmental Disorder and Congenital Malformation Risk in Offspring.JAMA network open · 2025Observational
- Safety concerns of paternal drug exposure on fertility, pregnancy and offspring: An analysis based on the FDA adverse event reporting system.Andrology · 2025Article
- Paternal family history of premature atherosclerotic disease and perinatal death: A population-based cohort study.PloS one · 2025Article
- Environmental and Genetic Traffic in the Journey from Sperm to Offspring.Biomolecules · 2023Review
- Nervous system drugs taken by future fathers and birth defects in offspring: a prospective registry-based cohort study.BMJ open · 2022Article
- 2019 Expert opinion on biological treatment use in inflammatory bowel disease management.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2019Article
- Preconceptional paternal antiepileptic drugs use and risk of congenital anomalies in offspring: a nationwide cohort study.European journal of epidemiology · 2019Article
- The forgotten father in obstetric medicine.Obstetric medicine · 2019Review
- Paternal use of antidepressants and offspring outcomes in Sweden: nationwide prospective cohort study.BMJ (Clinical research ed.) · 2018Observational
- Birth Outcomes in Children Fathered by Men Treated with Anti-TNF-α Agents Before Conception.The American journal of gastroenterology · 2016Article
- Investigating paternal preconception risk factors for adverse pregnancy outcomes in a population of internet users.Reproductive health · 2016Article
- Parental Substance Abuse As an Early Traumatic Event. Preliminary Findings on Neuropsychological and Personality Functioning in Young Drug Addicts Exposed to Drugs Early.Frontiers in psychology · 2016Article
- Birth outcomes in newborns fathered by men with multiple sclerosis exposed to disease-modifying drugs.CNS drugs · 2014Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsWe aimed to explore associations between drugs dispensed to the father prior to conception and pregnancy outcomes, such as pre-term birth, perinatal mortality, foetal growth retardation and birth defects.
methodsIn this cohort study, two population-based registries, the Medical Birth Registry of Norway and the Norwegian Prescription Database, were linked. The study cohort consisted of 340 000 pregnancies in 2004-10. The association between specific drugs dispensed to the fathers during the last 3 months prior to conception and pregnancy outcomes was explored by estimating odds ratios (ORs) using multivariate logistic regression.
resultsAbout one quarter (26%) of the fathers were dispensed at least one drug during the last 3 months prior to conception and 1.3% were dispensed at least one drug requiring special attention. Overall, the odds of different adverse pregnancy outcomes were not increased when the father had been dispensed drugs, i.e. the OR and 95% confidence intervals (CIs) for any birth defect when the fathers had been dispensed any drug were 0.99 (0.94, 1.0). When the fathers had been dispensed diazepam we found increased risk of perinatal mortality and growth retardation, with OR and 95% CIs of 2.2 (1.2, 3.9) and 1.4 (1.2, 1.6), respectively.
conclusionsLarge studies are necessary to reveal increased risk of rare outcomes as specific birth defects. Our study did not indicate that paternal drug exposure is an important risk factor for adverse pregnancy outcomes.
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