Evidence map›Paper›PMID 22897240›Full record

ArticleLangmuir : the ACS journal of surfaces and colloids2012

Chloroform-enhanced incorporation of hydrophobic gold nanocrystals into dioleoylphosphatidylcholine (DOPC) vesicle membranes.

Michael R Rasch, Yixuan Yu, Christian Bosoy, Brian W Goodfellow, Brian A Korgel

Abstract read
In one paragraph

Article in Langmuir : the ACS journal of surfaces and colloids, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 32 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Michael R RaschDepartment of Chemical Engineering, Texas Materials Institute, Center for Nano and Molecular Science and Technology, The University of Texas at Austin, Austin, Texas 78712-1062, United States.
Yixuan Yu
Christian Bosoy
Brian W Goodfellow
Brian A Korgel
The University of Texas at Austin · US

Funding

Metal nanoparticle-mediated diagnosis, targeting, and treatment of cancerR01CA132032 · NCI · UNIVERSITY OF TEXAS AT AUSTIN · PI TUNNELL, JAMES W · 2008 to 2012
$1.6M
NCI NIH HHS R01 CA132032
6 · The paper itself

Abstract

Vesicles of dioleoylphosphatidylcholine (DOPC) formed by extrusion (liposomes) with hydrophobic alkanethiol-capped Au nanocrystals were studied. Dodecanethiol-capped 1.8-nm-diameter Au nanocrystals accumulate in the lipid bilayer, but only when dried lipid-nanocrystal films were annealed with chloroform prior to hydration. Without chloroform annealing, the Au nanocrystals phase separate from DOPC and do not load into the liposomes. Au nanocrystals with slightly longer capping ligands of hexadecanethiol or with a larger diameter of 4.1 nm disrupted vesicle formation and created lipid assemblies with many internal lamellar attachments.

Indexed as

Hydrophobic and Hydrophilic InteractionsChloroformGoldLiposomesMetal NanoparticlesParticle SizePhosphatidylcholinesSulfhydryl CompoundsSurface Properties1,2-oleoylphosphatidylcholineChloroformdodecylmercaptanGoldLiposomesPhosphatidylcholinesSulfhydryl Compounds

Identifiers

PMID22897240
PMCPMC3510979
OpenAlexW2312576344

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.