ReviewACS chemical neuroscience2012
Dissecting neural function using targeted genome engineering technologies.
Review in ACS chemical neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Generation of IL17RB Knockout Cell Lines Using CRISPR/Cas9-Based Genome Editing.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Advancing ornamental plant breeding through genomic technologies: opportunities, challenges, and future directions.Functional & integrative genomics · 2025Review
- Review
- Genetic Engineering and Genome Editing Advances to Enhance Floral Attributes in Ornamental Plants: An Update.Plants (Basel, Switzerland) · 2023Review
- Review
- Systematic Studies of the Circadian Clock Genes Impact on Temperature Compensation and Cell Proliferation Using CRISPR Tools.Biology · 2021Article
- Advances in high-throughput methods for the identification of virus receptors.Medical microbiology and immunology · 2020Review
- Progress and Challenges in the Improvement of Ornamental Plants by Genome Editing.Plants (Basel, Switzerland) · 2020Review
- Genome Editing of theCells · 2020Article
- Efficient Production and Identification of CRISPR/Cas9-generated Gene Knockouts in the Model System Danio rerio.Journal of visualized experiments : JoVE · 2018Article
- CRISPR Genome Engineering for Human Pluripotent Stem Cell Research.Theranostics · 2017Review
- Genome-editing technologies and their potential application in horticultural crop breeding.Horticulture research · 2015Review
- Schizophrenia genetics: building the foundations of the future.Schizophrenia bulletin · 2015Article
- DNA methylation and its implications and accessibility for neuropsychiatric therapeutics.Annual review of pharmacology and toxicology · 2015Review
- Optimizing neuronal differentiation from induced pluripotent stem cells to model ASD.Frontiers in cellular neuroscience · 2014Review
- Genome engineering using the CRISPR-Cas9 system.Nature protocols · 2013Article
- Article
- DNA targeting specificity of RNA-guided Cas9 nucleases.Nature biotechnology · 2013Article
- A nanobody-based system using fluorescent proteins as scaffolds for cell-specific gene manipulation.Cell · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Designer DNA-binding proteins based on transcriptional activator-like effectors (TALEs) and zinc finger proteins (ZFPs) are easily tailored to recognize specific DNA sequences in a modular manner. They can be engineered to generate tools for targeted genome perturbation. Here, we review recent advances in these versatile technologies with a focus on designer nucleases for highly precise, efficient, and scarless gene modification. By generating double stranded breaks and stimulating cellular DNA repair pathways, TALE and ZF nucleases have the ability to modify the endogenous genome. We also discuss current applications of designer DNA-binding proteins in synthetic biology and disease modeling, novel effector domains for genetic and epigenetic regulation, and finally perspectives on using customizable DNA-binding proteins for interrogating neural function.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.