ArticleCirculation2012
Childhood air pollutant exposure and carotid artery intima-media thickness in young adults.
Article in Circulation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 3 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Association between fine particulate matter exposure and subclinical atherosclerosis: A meta-analysis.European journal of preventive cardiology · 2016Pooled it
- Association of Exposure to particular matter and Carotid Intima-Media Thickness: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2015Pooled it
- Air pollution and atherosclerosis: a cross-sectional analysis of four European cohort studies in the ESCAPE study.Environmental health perspectives · 2015Pooled it
- Effects of urban fine particulate matter and ozone on HDL functionality.Particle and fibre toxicology · 2016Trial
- Investigation of the Association between Long-term Ozone Exposure and Cardiovascular Disease: A Meta-Analysis Addressing Exposure Windows, Vulnerable Populations, and Spatial Variation.China CDC weekly · 2026Review
- Air pollution and depression symptoms in middle-aged and older adults in Los Angeles County.International archives of occupational and environmental health · 2025Article
- Ozone exposure and cardiovascular disease: A narrative review of epidemiology evidence and underlying mechanisms.Fundamental research · 2025Review
- Impact of childhood exposure to traffic related air pollution on adult cardiometabolic health: Exploring the role of perceived stress.Environmental research · 2024Article
- Insights into elastic fiber fragmentation: Mechanisms and treatment of aortic aneurysm in Marfan syndrome.Vascular pharmacology · 2023Review
- Modern Concepts of the Role of Fine Particles (PM 2.5) in the Genesis of Atherosclerosis and Myocardial Damage: Clinical and Epidemiological Data, the Main Pathophysiological Mechanisms.Current cardiology reviews · 2023Review
- The Role of Fine Particles (PM 2.5) in the Genesis of Atherosclerosis and Myocardial Damage: Emphasis on Clinical and Epidemiological Data, and Pathophysiological Mechanisms.Cardiology research · 2022Review
- Quantile regression to examine the association of air pollution with subclinical atherosclerosis in an adolescent population.Environment international · 2022Article
- Childhood traffic-related air pollution and adverse changes in subclinical atherosclerosis measures from childhood to adulthood.Environmental health : a global access science source · 2021Article
- The critical role of endothelial function in fine particulate matter-induced atherosclerosis.Particle and fibre toxicology · 2020Review
- Health Effects of Ozone on Respiratory Diseases.Tuberculosis and respiratory diseases · 2020Article
- Red Flag for Arterial Damage? Early Evidence of a Potential Connection with Ozone.Environmental health perspectives · 2019Article
- Residential Exposure to PMJournal of women's health (2002) · 2019Article
- Long-Term Exposure to Ambient Ozone and Progression of Subclinical Arterial Disease: The Multi-Ethnic Study of Atherosclerosis and Air Pollution.Environmental health perspectives · 2019Article
- Five-year exposure to PMInternational journal of hygiene and environmental health · 2019Article
- Clinical effects of air pollution on the central nervous system; a review.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2017Review
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundExposure to ambient air pollutants increases risk for cardiovascular health outcomes in adults. The contribution of childhood air pollutant exposure to cardiovascular health has not been thoroughly evaluated. METHODS AND
resultsThe Testing Responses on Youth study consists of 861 college students recruited from the University of Southern California in 2007 to 2009. Participants attended 1 study visit during which blood pressure, heart rate, and carotid artery intima-media thickness (CIMT) were assessed. Self-administered questionnaires collected information about health and sociodemographic characteristics, and a 12-hour fasting blood sample was drawn for lipid and biomarker analyses. Residential addresses were geocoded and used to assign cumulative air pollutant exposure estimates based on data derived from the U.S. Environmental Protection Agency's Air Quality System database. The associations between CIMT and air pollutants were assessed using linear regression analysis. Mean CIMT was 603 μm (±54 SD). A 2 standard deviation (SD) increase in childhood (aged 0-5 years) or elementary school (aged 6-12 years) O(3) exposure was associated with a 7.8-μm (95% confidence interval, -0.3-15.9) or 10.1-μm (95% confidence interval, 1.8-18.5) higher CIMT, respectively. Lifetime exposure to O(3) showed similar but nonsignificant associations. No associations were observed for PM(2.5), PM(10), or NO(2), although adjustment for these pollutants strengthened the childhood O(3) associations.
conclusionsChildhood exposure to O(3) may be a novel risk factor for CIMT in a healthy population of college students. Regulation of air pollutants and efforts that focus on limiting childhood exposures continue to be important public health goals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.