ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Plasticity of metabotropic glutamate receptor-dependent long-term depression in the anterior cingulate cortex after amputation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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Who cites it
60 citing papers in PubMed.
- AMPA receptor, neuroimaging, and chronic pain.Journal of anesthesia · 2026Review
- Altered Excitation-Inhibition Balance and mGluRInternational journal of molecular sciences · 2026Article
- GluK1-containing kainate receptor-dependent long-term depression in the anterior cingulate cortex modulates chronic pain.Journal of translational medicine · 2026Article
- Metabotropic Glutamate Receptor-Dependent Synaptic Plasticity in Age-Related Neurodegenerative Disorders.Neural plasticity · 2026Review
- Transcriptional signatures of aberrant brain functional network topology in chronic low back pain with lumbar disc herniation.Frontiers in molecular neuroscience · 2026Article
- Levodopa treatment: impacts and mechanisms throughout Parkinson's disease progression.Journal of neural transmission (Vienna, Austria : 1996) · 2025Review
- Cortical Potentiation in Chronic Neuropathic Pain and the Future Treatment.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Cortical Tagged Synaptic Long-Term Depression in the Anterior Cingulate Cortex of Adult Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Review
- Desipramine reverses remote memory deficits by activating calmodulin-CaMKII pathway in a UTX knockout mouse model of Kabuki syndrome.General psychiatry · 2024Article
- Review
- Synaptic Plasticity in the Pain-Related Cingulate and Insular Cortex.Biomedicines · 2022Review
- Long-Lasting, Pathway-Specific Impairment of a Novel Form of Spike-Timing-Dependent Long-Term Depression by Neuropathic Pain in the Anterior Cingulate Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Different Synaptic Plasticity After Physiological and Psychological Stress in the Anterior Insular Cortex in an Observational Fear Mouse Model.Frontiers in synaptic neuroscience · 2022Article
- Synaptic potentiation of anterior cingulate cortex contributes to chronic pain of Parkinson's disease.Molecular brain · 2021Article
- Brain-derived neurotrophic factor produced long-term synaptic enhancement in the anterior cingulate cortex of adult mice.Molecular brain · 2021Article
- Multiple synaptic connections into a single cortical pyramidal cell or interneuron in the anterior cingulate cortex of adult mice.Molecular brain · 2021Article
- The Medial Prefrontal Cortex as a Central Hub for Mental Comorbidities Associated with Chronic Pain.International journal of molecular sciences · 2020Review
- Cortical plasticity as synaptic mechanism for chronic pain.Journal of neural transmission (Vienna, Austria : 1996) · 2020Review
- Sex difference in synaptic plasticity in the anterior cingulate cortex of adult mice.Molecular brain · 2020Article
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10 authors.
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Abstract
Long-term depression (LTD) is a key form of synaptic plasticity important in learning and information storage in the brain. It has been studied in various cortical regions, including the anterior cingulate cortex (ACC). ACC is a crucial cortical region involved in such emotion-related physiological and pathological conditions as fear memory and chronic pain. In the present study, we used a multielectrode array system to map cingulate LTD in a spatiotemporal manner within the ACC. We found that low-frequency stimulation (1 Hz, 15 min) applied onto deep layer V induced LTD in layers II/III and layers V/VI. Cingulate LTD requires activation of metabotropic glutamate receptors (mGluRs), while L-type voltage-gated calcium channels and NMDA receptors also contribute to its induction. Peripheral amputation of the distal tail impaired ACC LTD, an effect that persisted for at least 2 weeks. The loss of LTD was rescued by priming ACC slices with activation of mGluR1 receptors by coapplying (RS)-3,5-dihydroxyphenylglycine and MPEP, a form of metaplasticity that involved the activation of protein kinase C. Our results provide in vitro evidence of the spatiotemporal properties of ACC LTD in adult mice. We demonstrate that tail amputation causes LTD impairment within the ACC circuit and that this can be rescued by activation of mGluR1.
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