ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
State-dependent modulation of breathing in urethane-anesthetized rats.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 84 citations in OpenAlex.
- Complex Three-Dimensional Rearing Environments Amplify Compensatory Plasticity Following Early Blindness.eNeuro · 2026Article
- Lateralization of Hippocampal Dentate Spikes and Sharp-Wave Ripples in Urethane Anesthetized Rats Depends on Cholinergic Tone.Hippocampus · 2025Article
- Cholinergic modulation of upper airway control: maturational changes and mechanisms at cellular and synaptic levels.Journal of neurophysiology · 2025Review
- Anesthetic effects on electrophysiological responses across the visual pathway.Scientific reports · 2024Article
- The Modulation by Anesthetics and Analgesics of Respiratory Rhythm in the Nervous System.Current neuropharmacology · 2024Review
- Characterizing brain stage-dependent pupil dynamics based on lateral hypothalamic activity.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Caffeine exacerbates seizure-induced death via postictal hypoxia.Scientific reports · 2023Article
- A Comparison of Brain-State Dynamics across Common Anesthetic Agents in Male Sprague-Dawley Rats.International journal of molecular sciences · 2022Article
- Infantile status epilepticus disrupts myelin development.Neurobiology of disease · 2022Article
- Spontaneous Multimodal Neural Transmission Suggests That Adult Spinal Networks Maintain an Intrinsic State of Readiness to Execute Sensorimotor Behaviors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Respiratory coupling between prefrontal cortex and hippocampus of rats anaesthetized with urethane in theta and non-theta states.The European journal of neuroscience · 2021Article
- Long-term stability of physiological signals within fluctuations of brain state under urethane anesthesia.PloS one · 2021Article
- Prefrontal-Hippocampal Pathways Through the Nucleus Reuniens Are Functionally Biased by Brain State.Frontiers in neuroanatomy · 2021Article
- Neural Correlates of Auditory Pattern Learning in the Auditory Cortex.Frontiers in neuroscience · 2021Article
- Differential modulation of active expiration during hypercapnia by the medullary raphe in unanesthetized rats.Pflugers Archiv : European journal of physiology · 2020Article
- Electrical stimulation of the ventral tegmental area evokes sleep-like state transitions under urethane anaesthesia in the rat medial prefrontal cortex via dopamine DThe European journal of neuroscience · 2020Article
- Sleep Disorders in Rodent Models of Parkinson's Disease.Frontiers in pharmacology · 2019Review
- Presynaptic Mechanisms and KCNQ Potassium Channels Modulate Opioid Depression of Respiratory Drive.Frontiers in physiology · 2019Article
- Hyperoxia enhances slow-wave forebrain states in urethane-anesthetized and naturally sleeping rats.Journal of neurophysiology · 2018Article
- Sleep awakens active expiration.The Journal of physiology · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 4 countries.
Funding
Abstract
Respiratory activity is most fragile during sleep, in particular during paradoxical [or rapid eye movement (REM)] sleep and sleep state transitions. Rats are commonly used to study respiratory neuromodulation, but rodent sleep is characterized by a highly fragmented sleep pattern, thus making it very challenging to examine different sleep states and potential pharmacological manipulations within them. Sleep-like brain-state alternations occur in rats under urethane anesthesia and may be an effective and efficient model for sleep itself. The present study assessed state-dependent changes in breathing and respiratory muscle modulation under urethane anesthesia to determine their similarity to those occurring during natural sleep. Rats were anesthetized with urethane and respiratory airflow, as well as electromyographic activity in respiratory muscles were recorded in combination with local field potentials in neocortex and hippocampus to determine how breathing pattern and muscle activity are modulated with brain state. Measurements were made in normoxic, hypoxic, and hypercapnic conditions. Results were compared with recordings made from rats during natural sleep. Brain-state alternations under urethane anesthesia were closely correlated with changes in breathing rate and variability and with modulation of respiratory muscle tone. These changes closely mimicked those observed in natural sleep. Of great interest was that, during both REM and REM-like states, genioglossus muscle activity was strongly depressed and abdominal muscle activity showed potent expiratory modulation. We demonstrate that, in urethane-anesthetized rats, respiratory airflow and muscle activity are closely correlated with brain-state transitions and parallel those shown in natural sleep, providing a useful model to systematically study sleep-related changes in respiratory control.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.