ArticleNeurology2012
C-reactive protein and familial risk for dementia: a phenotype for successful cognitive aging.
Article in Neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- What characterizes the exceptional cognition of superagers? A systematic review of multidomain biomarkers of successful cognitive aging.The Gerontologist · 2026Pooled it
- Impact of hs-CRP concentration on brain structure alterations and cognitive trajectory in Alzheimer's disease.Frontiers in aging neuroscience · 2023Article
- The Role of Inflammatory Biomarkers as a Diagnostic Tool for Possible Late-Life Cognitive Decline and Dementias.Advances in experimental medicine and biology · 2021Article
- Understanding the Physiological Links Between Physical Frailty and Cognitive Decline.Aging and disease · 2020Review
- Article
- Outcome age-based prediction of successful cognitive aging by total cholesterol.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2018Article
- The protected survivor model: Using resistant successful cognitive aging to identify protection in the very old.Medical hypotheses · 2018Article
- The association of high sensitivity C-reactive protein and incident Alzheimer disease in patients 60 years and older: The HUNT study, Norway.Immunity & ageing : I & A · 2018Article
- Dementia Risk and Protective Factors Differ in the Context of Memory Trajectory Groups.Journal of Alzheimer's disease : JAD · 2016Article
- Repeated systemic inflammation was associated with cognitive deficits in older Britons.Alzheimer's & dementia (Amsterdam, Netherlands) · 2016Article
- Cognitive Ageing in Great Britain in the New Century: Cohort Differences in Episodic Memory.PloS one · 2015Article
- Association of apolipoprotein E-e4 and dementia declines with age.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2014Article
- Long-term systemic inflammation and cognitive impairment in a population-based cohort.Journal of the American Geriatrics Society · 2014Article
- C-reactive protein, APOE genotype and longitudinal cognitive change in an older population.Age and ageing · 2014Article
- Epigenetic determinants of healthy and diseased brain aging and cognition.JAMA neurology · 2013Review
- CR1 and the "vanishing amyloid" hypothesis of Alzheimer's disease.Biological psychiatry · 2013Article
- Article
- Dementia in the oldest old: a multi-factorial and growing public health issue.Alzheimer's research & therapy · 2013Review
- Roles of C-reactive protein polymorphisms and life event changes on cognitive function in bipolar patients receiving valproate.International journal of immunopathology and pharmacologyArticle
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10 authors at 1 institution in 1 country.
Funding
Abstract
objectivesIdentifying phenotypes for successful cognitive aging, intact cognition into late-old age (>age 75), can help identify genes and neurobiological systems that may lead to interventions against and prevention of late-life cognitive impairment. The association of C-reactive protein (CRP) with cognitive impairment and dementia, observed primarily in young-elderly samples, appears diminished or reversed in late-old age (75+ years). A family history study determined if high CRP levels in late-old aged cognitively intact probands are associated with a reduced risk of dementia in their first-degree family members, suggesting a familial successful cognitive aging phenotype.
methodsThe primary sample was 1,329 parents and siblings of 277 cognitively intact male veteran probands at least 75 years old. The replication sample was 202 relatives of 51 cognitively intact community-ascertained probands at least 85 years old. Relatives were assessed for dementia by proband informant interview. Their hazard ratio (HR) for dementia as a function of the proband's log-transformed CRP was calculated using the proportional hazards model.
resultsCovarying for key demographics, higher CRP in probands was strongly associated with lower risk of dementia in relatives (HR = 0.55 [95% confidence interval (CI) 0.41, 0.74], p < 0.02). The replication sample relationship was in the same direction, stronger in magnitude, and also significant (HR = 0.15 [95% CI 0.06, 0.37], p < 0.0001).
conclusionsRelatives of successful cognitive aging individuals with high levels of CRP are relatively likely to remain free of dementia. High CRP in successful cognitive aging individuals may constitute a phenotype for familial-and thus possibly genetic-successful cognitive aging.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.