ArticleKidney international2012
Endothelial pentraxin 3 contributes to murine ischemic acute kidney injury.
Article in Kidney international, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06498336 (Specific miRNA Associated With Endothelial Dysfunction and Mitochondrial Damage in Patients With Septic Acute Kidney Injury), which is not on this map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Specific miRNA Associated With Endothelial Dysfunction and Mitochondrial Damage in Patients With Septic Acute Kidney Injury
Who cites it
24 citing papers in PubMed, 41 citations in OpenAlex.
- Putative novel mediators of acute kidney injury in critically ill patients: handling by continuous venovenous hemofiltration and effect of anticoagulation modalities.BMC nephrology · 2015Trial
- Pentraxin3 exacerbates acute pancreatitis injury by inhibiting oxidative phosphorylation pathway.Scientific reports · 2025Article
- Pentraxin 3 deficiency ameliorates streptozotocin-induced pancreatic toxicity via regulating ER stress and β-cell apoptosis.Molecules and cells · 2025Article
- Pentraxin-3 (PTX-3) as a potential biomarker for predicting death in hospitalized patients with COVID-19.Virology journal · 2024Article
- Article
- VEGFR2 insufficiency enhances phosphotoxicity and undermines Klotho's protection against peritubular capillary rarefaction and kidney fibrosis.American journal of physiology. Renal physiology · 2023Article
- Microvascular dysfunction and kidney disease: Challenges and opportunities?Microcirculation (New York, N.Y. : 1994) · 2021Review
- PTX3 Deficiency Promotes Enhanced Accumulation and Function of CD11cFrontiers in immunology · 2021Article
- Tissue Dependent Role of PTX3 During Ischemia-Reperfusion Injury.Frontiers in immunology · 2019Review
- Investigation of the Mechanism Underlying Calcium Dobesilate-Mediated Improvement of Endothelial Dysfunction and Inflammation Caused by High Glucose.Mediators of inflammation · 2019Article
- PTX3 in serum induces renal mesangial cell proliferation but has no effect on apoptosis.Experimental and therapeutic medicine · 2018Article
- Exogenous pentraxin-3 inhibits the reactive oxygen species-mitochondrial and apoptosis pathway in acute kidney injury.PloS one · 2018Article
- Study on Association of Pentraxin 3 and Diabetic Nephropathy in a Rat Model.Journal of diabetes research · 2018Article
- Association of Pentraxin 3 Gene Polymorphisms with Susceptibility to Diabetic Nephropathy.Medical science monitor : international medical journal of experimental and clinical research · 2017Article
- Astrocyte-Derived Pentraxin 3 Supports Blood-Brain Barrier Integrity Under Acute Phase of Stroke.Stroke · 2016Article
- Factor H-related protein 5 interacts with pentraxin 3 and the extracellular matrix and modulates complement activation.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Article
- Innate immune system: the no man's land where discover new biomarkers for gluten-related-disorders.Gastroenterology and hepatology from bed to bench · 2015Article
- The yin-yang of long pentraxin PTX3 in inflammation and immunity.Immunology letters · 2014Review
- Immune system modulation of kidney regeneration--mechanisms and implications.Nature reviews. Nephrology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Toll-like receptor 4 (TLR4), a receptor for damage-associated molecular pattern molecules and also the lipopolysaccharide receptor, is required for early endothelial activation leading to maximal inflammation and injury during murine ischemic acute kidney injury. DNA microarray analysis of ischemic kidneys from TLR4-sufficient and -deficient mice showed that pentraxin 3 (PTX3) was upregulated only on the former while transgenic knockout of PTX3 ameliorated acute kidney injury. PTX3 was expressed predominantly on peritubular endothelia of the outer medulla of the kidney in control mice. Acute kidney injury increased PTX3 protein in the kidney and the plasma where it may be a biomarker of the injury. Stimulation by hydrogen peroxide, or the TLR4 ligands recombinant human high-mobility group protein B1 or lipopolysaccharide, induced PTX3 expression in the Mile Sven 1 endothelial cell line and in primary renal endothelial cells, suggesting that endothelial PTX3 was induced by pathways involving TLR4 and reactive oxygen species. This increase was inhibited by conditional endothelial knockout of myeloid differentiation primary response gene 88, a mediator of a TLR4 intracellular signaling pathway. Compared to wild-type mice, PTX3 knockout mice had decreased endothelial expression of cell adhesion molecules at 4 h of reperfusion, possibly contributing to a decreased early maladaptive inflammation in the kidneys of knockout mice. At 24 h of reperfusion, PTX3 knockout increased expression of endothelial adhesion molecules when regulatory and reparative leukocytes enter the kidney. Thus, endothelial PTX3 plays a pivotal role in the pathogenesis of ischemic acute kidney injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.