ArticleThe Journal of investigative dermatology2012
HB-EGF, the growth factor that accelerates keratinocyte migration, but slows proliferation.
Article in The Journal of investigative dermatology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 14 citations in OpenAlex.
- Nuclear IL-33 Plays an Important Role in EGFR-Mediated Keratinocyte Migration by Regulating the Activation of Signal Transducer and Activator of Transcription 3 and NF-κB.JID innovations : skin science from molecules to population health · 2023Article
- The progress and challenges of circRNA for diabetic foot ulcers: A mini-review.Frontiers in endocrinology · 2022Review
- IgE Autoreactivity in Atopic Dermatitis: Paving the Road for Autoimmune Diseases?Antibodies (Basel, Switzerland) · 2020Review
- Circular RNA hsa_circ_0084443 Is Upregulated in Diabetic Foot Ulcer and Modulates Keratinocyte Migration and Proliferation.Advances in wound care · 2020Article
- Keratinocyte Function in Normal and Diabetic Wounds and Modulation by FOXO1.Journal of diabetes research · 2020Review
- Local cortisol activation is involved in EGF-induced immunosuppression.Dermato-endocrinology · 2017Article
- Role of EGF receptor ligands in TCDD-induced EGFR down-regulation and cellular proliferation.Chemico-biological interactions · 2016Article
- MicroRNA-132 enhances transition from inflammation to proliferation during wound healing.The Journal of clinical investigation · 2015Article
- Integrins in Wound Healing.Advances in wound care · 2014Review
- SPINK9 stimulates metalloprotease/EGFR-dependent keratinocyte migration via purinergic receptor activation.The Journal of investigative dermatology · 2014Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Among epidermal growth factors, heparin-binding epidermal growth factor (EGF)-like growth factor (HB-EGF) is expressed unlike others, and produces unusual effects on keratinocytes. A new report illustrates the development of a motile phenotype characterized by signs of epithelial-mesenchymal transition, reduced proliferation, and altered expression of epidermal markers. We comment on differences between endogenous HB-EGF and recombinant factor, about opportune and inopportune situations of HB-EGF overexpression by epidermal keratinocytes, as well as about the consequences on epidermal tissues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.