ArticleGenes & development2012
Photoactivated phytochromes interact with HEMERA and promote its accumulation to establish photomorphogenesis in Arabidopsis.
Article in Genes & development, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
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Who cites it
69 citing papers in PubMed, 104 citations in OpenAlex.
- Nucleoporin Nup96 promotes plant photomorphogenesis by facilitating phyB photobody formation and HOS1-mediated PIF5 degradation in Arabidopsis.Plant communications · 2026Article
- Phytochrome B sets condensate number through graded nucleator states and seeding-site efficacy.Nature communications · 2026Article
- Twenty-five years of photobodies: formation, composition, and the 2-compartment logic of phytochrome B signaling.Plant physiology · 2026Review
- Phytochrome-mediated light perception in dodders drives haustorium development through epigenetic mechanisms.Plant & cell physiology · 2026Article
- Intragenic suppressor screen of YHB identifies novel and known loss-of-function alleles of Arabidopsis phytochrome B.bioRxiv : the preprint server for biology · 2026Article
- Light-regulated dual-targeting of NUCLEAR CONTROL OF PEP ACTIVITY establishes photomorphogenesis via interorganellar communication.Plant physiology · 2025Article
- A multisensor high-temperature signaling framework for triggering daytime thermomorphogenesis in Arabidopsis.Nature communications · 2025Article
- TheProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Integrated Study of Fluorescence Enhancement in the Y176H Variant of Cyanobacterial Phytochrome Cph1.Biochemistry · 2025Article
- Integrative phenotyping analyses reveal the relevance of the phyB-PIF4 pathway in Arabidopsis thaliana reproductive organs at high ambient temperature.BMC plant biology · 2024Article
- A cytosol-tethered YHB variant of phytochrome B retains photomorphogenic signaling activity.Plant molecular biology · 2024Article
- What is going on inside of phytochrome B photobodies?The Plant cell · 2024Review
- Photobody formation spatially segregates two opposing phytochrome B signaling actions of PIF5 degradation and stabilization.Nature communications · 2024Article
- Dissection of Daytime and Nighttime Thermoresponsive Hypocotyl Elongation in Arabidopsis.Methods in molecular biology (Clifton, N.J.) · 2024Article
- FAR-RED INSENSITIVE 219 and phytochrome B corepress shade avoidance via modulating nuclear speckle formation.Plant physiology · 2023Article
- FERONIA coordinates plant growth and salt tolerance via the phosphorylation of phyB.Nature plants · 2023Article
- Role of plastids and mitochondria in the early development of seedlings in dark growth conditions.Frontiers in plant science · 2023Review
- Anterograde signaling controls plastid transcription via sigma factors separately from nuclear photosynthesis genes.Nature communications · 2022Article
- PIFs- and COP1-HY5-mediated temperature signaling in higher plants.Stress biology · 2022Review
- High-resolution map of plastid-encoded RNA polymerase binding patterns demonstrates a major role of transcription in chloroplast gene expression.The Plant journal : for cell and molecular biology · 2022Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Plant development is profoundly regulated by ambient light cues through the red/far-red photoreceptors, the phytochromes. Early phytochrome signaling events include the translocation of phytochromes from the cytoplasm to subnuclear domains called photobodies and the degradation of antagonistically acting phytochrome-interacting factors (PIFs). We recently identified a key phytochrome signaling component, HEMERA (HMR), that is essential for both phytochrome B (phyB) localization to photobodies and PIF degradation. However, the signaling mechanism linking phytochromes and HMR is unknown. Here we show that phytochromes directly interact with HMR to promote HMR protein accumulation in the light. HMR binds more strongly to the active form of phytochromes. This interaction is mediated by the photosensory domains of phytochromes and two phytochrome-interacting regions in HMR. Missense mutations in either HMR or phyB that alter the phytochrome/HMR interaction can also change HMR levels and photomorphogenetic responses. HMR accumulation in a constitutively active phyB mutant (YHB) is required for YHB-dependent PIF3 degradation in the dark. Our genetic and biochemical studies strongly support a novel phytochrome signaling mechanism in which photoactivated phytochromes directly interact with HMR and promote HMR accumulation, which in turn mediates the formation of photobodies and the degradation of PIFs to establish photomorphogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.