Evidence map›Paper›PMID 22895250›Full record

ArticleGenes & development2012

Seeing the forest for the trees: a wide perspective on RNA-directed DNA methylation.

Huiming Zhang, Jian-Kang Zhu

Abstract readComment
In one paragraph

Article in Genes & development, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Regulatory link between DNA methylation and active demethylation in Arabidopsis.Proceedings of the National Academy of Sciences of the United States of America · 2015
    Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Huiming ZhangDepartment of Horticulture and Landscape Architecture, Purdue University, West Lafayette, Indiana 47907, USA.
Jian-Kang Zhu

Funding

CALCIUM SIGNALING--INTRACELL ION HOMEOSTASIS REGULATIONR01GM059138 · NIGMS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI ZHU, JIAN-KANG · 1999 to 2015
$4.4M
DNA Demethylation and Transcriptional Gene SilencingR01GM070795 · NIGMS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI ZHU, JIAN-KANG · 2004 to 2015
$4.0M
NIGMS NIH HHS R01 GM059138NIGMS NIH HHS R01GM059138NIGMS NIH HHS R01 GM070795NIGMS NIH HHS R01GM070795
6 · The paper itself

Abstract

In this issue of Genes & Development, Wierzbicki and colleagues (pp. 1825-1836) examine the current model of RNA-directed DNA methylation (RdDM) by determining genome-wide distributions of RNA polymerase V (Pol V) occupancy, siRNAs, and DNA methylation. Their data support the key role of base-pairing between Pol V transcripts and siRNAs in targeting de novo DNA methylation. Importantly, the study also reveals unexpected complexity and provides a global view of the RdDM pathway.

Indexed as

ArabidopsisArabidopsis ProteinsDNA-Directed RNA PolymerasesDNA MethylationGenome, PlantCytosineRNA, Small InterferingArabidopsis ProteinsCytosineDNA-Directed RNA PolymerasesRNA polymerase IV, ArabidopsisRNA polymerase V, ArabidopsisRNA, Small Interfering

Identifiers

PMID22895250
PMCPMC3426756

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.