ArticleCell cycle (Georgetown, Tex.)2012
Transcriptional targeting by microRNA-polycomb complexes: a novel route in cell fate determination.
Article in Cell cycle (Georgetown, Tex.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 40 citations in OpenAlex.
- Nuclear miRNAs: Gene Regulation Activities.International journal of molecular sciences · 2024Review
- Article
- MicroRNAs reshape the immunity of insects in response to bacterial infection.Frontiers in immunology · 2023Review
- Transcriptomic analysis reveals myometrial topologically associated domains linked to the onset of human term labour.Molecular human reproduction · 2022Article
- Epigenetic and metabolic regulation of epidermal homeostasis.Experimental dermatology · 2021Review
- Increased Extracellular Matrix Protein Production in Chronic Diabetic Complications: Implications of Non-Coding RNAs.Non-coding RNA · 2019Review
- Bidirectional regulation of osteogenic differentiation by the FOXO subfamily of Forkhead transcription factors in mammalian MSCs.Cell proliferation · 2019Review
- MicroRNA-204 Is Necessary for Aldosterone-Stimulated T-Type Calcium Channel Expression in Cardiomyocytes.International journal of molecular sciences · 2018Article
- Epigenetic treatment of solid tumours: a review of clinical trials.Clinical epigenetics · 2015Review
- Involvement of MicroRNA in T-Cell Differentiation and Malignancy.International journal of hematology-oncology and stem cell research · 2015Review
- Epigenetic effects of cadmium in cancer: focus on melanoma.Current genomics · 2014Article
- Transcriptional fine-tuning of microRNA-223 levels directs lineage choice of human hematopoietic progenitors.Cell death and differentiation · 2014Article
- An integrative framework identifies alternative splicing events in colorectal cancer development.Molecular oncology · 2014Article
- MicroRNAs as novel regulators of stem cell fate.World journal of stem cells · 2013Review
- RNA-guided diagnostics and therapeutics for next-generation individualized nanomedicine.The Journal of clinical investigation · 2013Article
- Article
- Cigarette smoke mediates epigenetic repression of miR-487b during pulmonary carcinogenesis.The Journal of clinical investigation · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Advances in the understanding of the epigenetic events underlying the regulation of developmental genes expression and cell lineage commitment are revealing novel regulatory networks. These also involve distinct components of the epigenetic pathways, including chromatin histone modification, DNA methylation, repression by polycomb complexes and microRNAs. Changes in chromatin structure, DNA methylation status and microRNA expression levels represent flexible, reversible and heritable mechanisms for the maintenance of stem cell states and cell fate decisions. We recently provided novel evidence showing that microRNAs, besides determining the post-transcriptional gene silencing of their targets, also bind to evolutionarily conserved complementary genomic seed-matches present on target gene promoters. At these sites, microRNAs can function as a critical interface between chromatin remodeling complexes and the genome for transcriptional gene silencing. Here, we discuss our novel findings supporting a role of the transcriptional chromatin targeting by polycomb-microRNA complexes in lineage fate determination of human hematopoietic cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.