ArticleCell cycle (Georgetown, Tex.)2012
Human telomerase reverse transcriptase (hTERT) is a target gene of β-catenin in human colorectal tumors.
Article in Cell cycle (Georgetown, Tex.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- The role of the WD40-repeat protein family in cancer.Molecular cancer · 2026Review
- Combining old and new concepts in targeting telomerase for cancer therapy: transient, immediate, complete and combinatory attack (TICCA).Cancer cell international · 2023Review
- Olfactomedin 4 associates with expression of differentiation markers but not with properties of cancer stemness, EMT nor metastatic spread in colorectal cancer.The journal of pathology. Clinical research · 2023Article
- Article
- Exploring the Interplay of Telomerase Reverse Transcriptase and β-Catenin in Hepatocellular Carcinoma.Cancers · 2021Review
- Mutual regulation between chicken telomerase reverse transcriptase and the Wnt/β-catenin signalling pathway inhibits apoptosis and promotes the replication of ALV-J in LMH cells.Veterinary research · 2021Article
- Exosomal miR-1255b-5p targets human telomerase reverse transcriptase in colorectal cancer cells to suppress epithelial-to-mesenchymal transition.Molecular oncology · 2020Article
- Lithium and the Interplay Between Telomeres and Mitochondria in Bipolar Disorder.Frontiers in psychiatry · 2020Review
- Cross-Talk between Wnt and Hh Signaling Pathways in the Pathology of Basal Cell Carcinoma.International journal of environmental research and public health · 2018Review
- Discovery of proteins associated with a predefined genomic locus via dCas9-APEX-mediated proximity labeling.Nature methods · 2018Article
- Therapeutic targeting of replicative immortality.Seminars in cancer biology · 2015Review
- Sustained proliferation in cancer: Mechanisms and novel therapeutic targets.Seminars in cancer biology · 2015Review
- miR-346 and miR-138 competitively regulate hTERT in GRSF1- and AGO2-dependent manners, respectively.Scientific reports · 2015Article
- Glucose-regulated protein 58 modulates β-catenin protein stability in a cervical adenocarcinoma cell line.BMC cancer · 2014Article
- MACC1 promotes carcinogenesis of colorectal cancer via β-catenin signaling pathway.Oncotarget · 2014Article
- GSK-3 as potential target for therapeutic intervention in cancer.Oncotarget · 2014Review
- Epithelial-mesenchymal transition induces endoplasmic-reticulum-stress response in human colorectal tumor cells.PloS one · 2014Article
- α-catenin. A tumor suppressor beyond adherens junctions.Cell cycle (Georgetown, Tex.) · 2014Article
- Overexpression of a novel regulator of p120 catenin, NLBP, promotes lung adenocarcinoma proliferation.Cell cycle (Georgetown, Tex.) · 2013Article
- Telomere protection and TRF2 expression are enhanced by the canonical Wnt signalling pathway.EMBO reports · 2013Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The majority of colorectal cancers (CRCs) are characterized by a dysregulated canonical Wnt-signaling pathway leading to the stabilization and subsequent cellular increase and accumulation of β-catenin. After translocation into the nucleus, it acts as a transcription factor resulting in the expression of β-catenin target genes. These resemble most of the hallmarks of cancer except eternal life. The central mediator of this hallmark is hTERT (human telomerase reverse transcriptase). The hTERT gene is regulated, besides others, by the transcription factor c-Myc and, thus, indirectly via β-catenin as c-Myc is a β-catenin target gene. Interestingly, the expression patterns of hTERT and β-catenin, but not c-Myc are overlapping, probably because c-Myc is not only regulated by β-catenin, but also by many other transcription factors and pathways. Therefore, we argued that hTERT might be a direct target gene of β-catenin. In this study, we show evidence that β-catenin directly regulates the expression of the hTERT gene.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.