ArticleCell cycle (Georgetown, Tex.)2012
The RelB subunit of NFκB acts as a negative regulator of circadian gene expression.
Article in Cell cycle (Georgetown, Tex.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 63 citations in OpenAlex.
- Circadian clock and its potential as a therapy for ischemic heart disease.Cell communication and signaling : CCS · 2026Review
- Inflammation-associated brain functional network topological disruption in female nurses with SWSD: associations with symptoms and transcriptomics.Frontiers in immunology · 2026Article
- Basic helix-loop-helix ARNT like 1 regulates the function of immune cells and participates in the development of immune-related diseases.Burns & trauma · 2025Review
- Lifelong Chronic Sleep Disruption in a Mouse Model of Traumatic Brain Injury.Neurotrauma reports · 2024Article
- Circadian mechanisms in adipose tissue bioenergetics and plasticity.Genes & development · 2023Review
- The circadian control of tryptophan metabolism regulates the host response to pulmonary fungal infections.PNAS nexus · 2023Article
- Gut Microbiota and Time-Restricted Feeding/Eating: A Targeted Biomarker and Approach in Precision Nutrition.Nutrients · 2023Review
- E-box binding transcription factors in cancer.Frontiers in oncology · 2023Review
- Circadian Disruption and Consequences on Innate Immunity and Inflammatory Response.International journal of molecular sciences · 2022Review
- Circadian rhythms in infectious diseases and symbiosis.Seminars in cell & developmental biology · 2022Review
- Article
- Emerging Insight Into the Role of Circadian Clock Gene BMAL1 in Cellular Senescence.Frontiers in endocrinology · 2022Review
- Role of sleep deprivation in immune-related disease risk and outcomes.Communications biology · 2021Review
- NF-κB modifies the mammalian circadian clock through interaction with the core clock protein BMAL1.PLoS genetics · 2021Article
- The Circadian Protein PER1 Modulates the Cellular Response to Anticancer Treatments.International journal of molecular sciences · 2021Article
- The interplay between mast cells, pineal gland, and circadian rhythm: Links between histamine, melatonin, and inflammatory mediators.Journal of pineal research · 2021Review
- Chronic Exposure to Continuous Brightness or Darkness Modulates Immune Responses and Ameliorates the Antioxidant Enzyme System in Male Rats.Frontiers in veterinary science · 2021Article
- Proinflammatory Cytokines Perturb Mouse and Human Pancreatic Islet Circadian Rhythmicity and Induce Uncoordinated β-Cell Clock Gene Expression via Nitric Oxide, Lysine Deacetylases, and Immunoproteasomal Activity.International journal of molecular sciences · 2020Article
- Core clock gene Bmal1 deprivation impairs steroidogenesis in mice luteinized follicle cells.Reproduction (Cambridge, England) · 2020Article
- Molecular Interactions Between Components of the Circadian Clock and the Immune System.Journal of molecular biology · 2020Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The circadian system controls a large array of physiological and metabolic functions. The molecular organization of the circadian clock is complex, involving various elements organized in feedback regulatory loops. Here we demonstrate that the RelB subunit of NFκB acts as a repressor of circadian transcription. RelB physically interacts with the circadian activator BMAL1 in the presence of CLOCK to repress circadian gene expression at the promoter of the clock-controlled gene Dbp. The repression is independent of the circadian negative regulator CRY. Notably, RelB -/- fibroblasts have profound alterations of circadian genes expression. These findings reveal a previously unforeseen function for RelB as an important regulator of the mammalian circadian system in fibroblasts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.