ArticleJournal of psychiatry & neuroscience : JPN2013
Functional network connectivity of pain-related resting state networks in somatoform pain disorder: an exploratory fMRI study.
Article in Journal of psychiatry & neuroscience : JPN, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neural correlates of co-occurring pain and depression: an activation-likelihood estimation (ALE) meta-analysis and systematic review.Translational psychiatry · 2022Pooled it
- A Study of the Brain Functional Network of Post-Stroke Depression in Three Different Lesion Locations.Scientific reports · 2017Trial
- MRI-Based Brain Signatures of Chemotherapy-Induced Peripheral Neuropathy in Cancer Patients: A Systematic Review and Meta-Analysis.Diagnostics (Basel, Switzerland) · 2026Review
- Abnormal lymphatic system function in patients with chronic neck and shoulder pain: neuroimaging evidence from DTI-ALPS.Frontiers in molecular neuroscience · 2026Article
- Predicting the onset of internalizing disorders in early adolescence using deep learning optimized with AI.Frontiers in psychiatry · 2025Article
- Alexithymia mediates the pathway from negative life events to somatic symptoms: a cross-sectional study in a psychosomatic outpatient sample.Frontiers in psychiatry · 2025Article
- Investigating the brain functional abnormalities underlying pain hypervigilance in chronic neck and shoulder pain: a resting-state fMRI study.Neuroradiology · 2024Article
- Alteration of static and dynamic intrinsic brain activity induced by short-term spinal cord stimulation in postherpetic neuralgia patients.Frontiers in neuroscience · 2023Article
- Bilateral Anterior Capsulotomy for the Treatment of Refractory Somatic Symptom Disorder: A Case Report.Frontiers in integrative neuroscience · 2021Article
- A neuroimaging marker for predicting longitudinal changes in pain intensity of subacute back pain based on large-scale brain network interactions.Scientific reports · 2020Article
- Default mode network changes in fibromyalgia patients are largely dependent on current clinical pain.NeuroImage · 2020Article
- Static and Dynamic Changes of Amplitude of Low-Frequency Fluctuations in Cervical Discogenic Pain.Frontiers in neuroscience · 2020Article
- Hallucinations, somatic-functional disorders of PD-DLB as expressions of thalamic dysfunction.Movement disorders : official journal of the Movement Disorder Society · 2019Review
- Increased Nucleus Accumbens Connectivity in Resting-State Patients With Drug-Naive, First-Episode Somatization Disorder.Frontiers in psychiatry · 2019Article
- Network Alterations in Comorbid Chronic Pain and Opioid Addiction: An Exploratory Approach.Frontiers in human neuroscience · 2019Article
- Somatic symptoms disorders in Parkinson's disease are related to default mode and salience network dysfunction.NeuroImage. Clinical · 2019Article
- Modular organization of brain resting state networks in patients with classical trigeminal neuralgia.NeuroImage. Clinical · 2019Article
- Article
- Abnormality of spontaneous brain activities in patients with chronic neck and shoulder pain: A resting-state fMRI study.The Journal of international medical research · 2017Article
- Altered resting-state intra- and inter- network functional connectivity in patients with persistent somatoform pain disorder.PloS one · 2017Article
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Authors and funding
6 authors.
Funding
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Abstract
backgroundWithout stimulation, the human brain spontaneously produces highly organized, low-frequency fluctuations of neural activity in intrinsic connectivity networks (ICNs). Furthermore, without adequate explanatory nociceptive input, patients with somatoform pain disorder experience pain symptoms, thus implicating a central dysregulation of pain homeostasis. The present study aimed to test whether interactions among pain-related ICNs, such as the default mode network (DMN), cingular-insular network (CIN) and sensorimotor network (SMN), are altered in somatoform pain during resting conditions.
methodsPatients with somatoform pain disorder and healthy controls underwent resting functional magnetic resonance imaging that lasted 370 seconds. Using a data-driven approach, the ICNs were isolated, and the functional network connectivity (FNC) was computed.
resultsTwenty-one patients and 19 controls enrolled in the study. Significant FNC (p < 0.05, corrected for false discovery rate) was detected between the CIN and SMN/anterior DMN, the anterior DMN and posterior DMN/SMN, and the posterior DMN and SMN. Interestingly, no group differences in FNC were detected. LIMITATIONS: The most important limitation of this study was the relatively short resting state paradigm.
conclusionTo our knowledge, our results demonstrated for the first time the resting FNC among pain-related ICNs. However, our results suggest that FNC signatures alone are not able to characterize the putative central dysfunction underpinning somatoform pain disorder.
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