ArticleJournal of biomedical optics2012
Experimental validation of an inverse fluorescence Monte Carlo model to extract concentrations of metabolically relevant fluorophores from turbid phantoms and a murine tumor model.
Article in Journal of biomedical optics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
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- Importance sampling-accelerated simulation of full-spectrum backscattered diffuse reflectance.Biomedical optics express · 2023Article
- Adaptive Design of Fluorescence Imaging Systems for Custom Resolution, Fields of View, and Geometries.BME frontiers · 2023Article
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- Near-simultaneous quantification of glucose uptake, mitochondrial membrane potential, and vascular parameters in murine flank tumors using quantitative diffuse reflectance and fluorescence spectroscopy.Biomedical optics express · 2018Article
- Bio-physically plausible visualization of highly scattering fluorescent neocortical models for in silico experimentation.BMC bioinformatics · 2017Article
- Intraoperative optical assessment of photodynamic therapy response of superficial oral squamous cell carcinoma.Journal of biomedical optics · 2016Article
- Quantitative imaging of light-triggered doxorubicin release.Biomedical optics express · 2015Article
- Non-invasive, simultaneous quantification of vascular oxygenation and glucose uptake in tissue.PloS one · 2015Article
- Recovery of intrinsic fluorescence from single-point interstitial measurements for quantification of doxorubicin concentration.Lasers in surgery and medicine · 2013Article
- Optical and radioiodinated tethered Hsp90 inhibitors reveal selective internalization of ectopic Hsp90 in malignant breast tumor cells.Chemistry & biology · 2013Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
An inverse Monte Carlo based model has been developed to extract intrinsic fluorescence from turbid media. The goal of this work was to experimentally validate the model to extract intrinsic fluorescence of three biologically meaningful fluorophores related to metabolism from turbid media containing absorbers and scatterers. Experimental studies were first carried out on tissue-mimicking phantoms that contained individual fluorophores and their combinations, across multiple absorption, scattering, and fluorophore concentrations. The model was then tested in a murine tumor model to determine both the kinetics of fluorophore uptake as well as overall tissue fluorophore concentration through extraction of the intrinsic fluorescence of an exogenous contrast agent that reports on glucose uptake. Results show the model can be used to recover the true intrinsic fluorescence spectrum with high accuracy (R(2)=0.988) as well as accurately compute fluorophore concentration in both single and multiple fluorophores phantoms when appropriate calibration standards are available. In the murine tumor, the model-corrected intrinsic fluorescence could be used to differentiate drug dose injections between different groups. A strong linear correlation was observed between the extracted intrinsic fluorescence intensity and injected drug dose, compared with the distorted turbid tissue fluorescence.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.