Evidence map›Paper›PMID 22894415›Full record

ArticleMedical physics2012

Consistency of breast density measured from the same women in four different MR scanners.

Jeon-Hor Chen, Siwa Chan, Yi-Jui Liu, Dah-Cherng Yeh, Chih-Kai Chang, Li-Kuang Chen, Wei-Fan Pan, Chih-Chen Kuo, Muqing Lin, Daniel H E Chang and 2 more

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In one paragraph

Article in Medical physics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Jeon-Hor ChenTu and Yuen Center for Functional Onco-Imaging of Department of Radiological Science, University of California Irvine, California 92697-5020, USA. jeonhc@uci.edu
Siwa Chan
Yi-Jui Liu
Dah-Cherng Yeh
Chih-Kai Chang
Li-Kuang Chen
Wei-Fan Pan
Chih-Chen Kuo
Muqing Lin
Daniel H E Chang
Peter T Fwu
Min-Ying Su
University of California, Irvine · USChina Medical University · TWTaichung Veterans General Hospital · TWFeng Chia University · TW

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Christine Hui · 1994 to 2026
$57.9M
Prediction of Neoadjuvant Chemo Pathological Response Using MRI MarkersR01CA127927 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI SU, MIN-YING L. · 2008 to 2017
$5.0M
Evaluation of 3D MRI-Based Quantitative Breast Density for ChemopreventionR03CA136071 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHEN, JEON-HOR · 2009 to 2010
$153k
NCI NIH HHS P30 CA062203NCI NIH HHS R01 CA127927NCI NIH HHS R03 CA136071
6 · The paper itself

Abstract

purposeTo compare the breast volume (BV), fibroglandular tissue volume (FV), and percent density (PD) measured from breast MRI of the same women using four different MR scanners.

methodsThe study was performed in 34 healthy Asian volunteers using two 1.5T (GE and Siemens) and two 3T (GE and Philips) MR scanners. The BV, FV, and PD were measured on nonfat-suppressed T1-weighted images using a comprehensive computer algorithm-based segmentation method. The scanner-to-scanner measurement difference, and the coefficient of variation (CV) among the four scanners were calculated. The measurement variation between two density morphological patterns presenting as the central type and the intermingled type was separately analyzed and compared.

resultsAll four scanners provided satisfactory image quality allowing for successful completion of the segmentation processes. The measured parameters between each pair of MR scanners were highly correlated, with R(2) ≥ 0.95 for BV, R(2) ≥ 0.99 for FV, and R(2) ≥ 0.97 for PD in all comparisons. The mean percent differences between each pair of scanners were 5.9%-7.8% for BV, 5.3%-6.5% for FV, 4.3%-7.3% for PD; with the overall CV of 5.8% for BV, 4.8% for FV, and 4.9% for PD. The variation of FV was smaller in the central type than in the intermingled type (p = 0.04).

conclusionsThe results showed that the variation of FV and PD measured from four different MR scanners is around 5%, suggesting the parameters measured using different scanners can be used for a combined analysis in a multicenter study.

Indexed as

Adipose TissueAdultAlgorithmsAsian PeopleBreastEquipment DesignFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMiddle AgedModels, StatisticalReproducibility of Results

Identifiers

PMID22894415
PMCPMC3411588
OpenAlexW1986068939

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.