ArticleEuropean journal of psychotraumatology2012
Examining potential contraindications for prolonged exposure therapy for PTSD.
Article in European journal of psychotraumatology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
70 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Impact of comorbid personality disorders on psychotherapy for post-traumatic stress disorder: systematic review and meta-analysis.European journal of psychotraumatology · 2021Pooled it
- Interventions for adults with a history of complex traumatic events: the INCiTE mixed-methods systematic review.Health technology assessment (Winchester, England) · 2020Pooled it
- The STORY MINE Digital Recovery Narrative Intervention for Personal Recovery in Mental Health Care: Pilot Randomized Controlled Trial.JMIR formative research · 2026Trial
- Comparing the effect of prolonged exposure therapy (PET) and metacognitive therapy (MCT) on the quality of life among veterans with PTSD.Military psychology : the official journal of the Division of Military Psychology, American Psychological Association · 2024Trial
- Skills training followed by either EMDR or narrative therapy for posttraumatic stress disorder in adult survivors of childhood abuse: a randomized controlled trial.European journal of psychotraumatology · 2024Trial
- Trauma-focused and personality disorder treatment for posttraumatic stress disorder and comorbid cluster C personality disorder: a randomized clinical trial.European journal of psychotraumatology · 2024Trial
- Predictors and moderators of treatment outcomes in phase-based treatment and trauma-focused treatments in patients with childhood abuse-related post-traumatic stress disorder.European journal of psychotraumatology · 2023Trial
- Substance use predictors of attendance among veterans in integrated PTSD and alcohol use disorder treatment.Journal of substance abuse treatment · 2021Trial
- Effect of Prolonged Exposure, intensified Prolonged Exposure and STAIR+Prolonged Exposure in patients with PTSD related to childhood abuse: a randomized controlled trial.European journal of psychotraumatology · 2021Trial
- Efficacy of Integrated Exposure Therapy vs Integrated Coping Skills Therapy for Comorbid Posttraumatic Stress Disorder and Alcohol Use Disorder: A Randomized Clinical Trial.JAMA psychiatry · 2019Trial
- Lagged effects of substance use on PTSD severity in a randomized controlled trial with modified prolonged exposure and relapse prevention.Journal of consulting and clinical psychology · 2018Trial
- Effectiveness of EMDR in patients with substance use disorder and comorbid PTSD: study protocol for a randomized controlled trial.BMC psychiatry · 2017Trial
- Study design, interventions, and baseline characteristics for the Substance use and TRauma Intervention for VEterans (STRIVE) trial.Contemporary clinical trials · 2016Trial
- Effectiveness and feasibility of Narrative Exposure Therapy (NET) in patients with borderline personality disorder and posttraumatic stress disorder - a pilot study.BMC psychiatry · 2016Trial
- Baseline psychophysiological and cortisol reactivity as a predictor of PTSD treatment outcome in virtual reality exposure therapy.Behaviour research and therapy · 2016Trial
- The influence of the dissociative subtype of posttraumatic stress disorder on treatment efficacy in female veterans and active duty service members.Journal of consulting and clinical psychology · 2016Trial
- A behavioral intervention for war-affected youth in Sierra Leone: a randomized controlled trial.Journal of the American Academy of Child and Adolescent Psychiatry · 2014Trial
- Trial
- From Bench to Bedside: Understanding General Anesthetics' Impact on PTSD.Current neuropharmacology · 2026Review
- Enhancing Agency in Posttraumatic Stress Disorder Therapies Through Sensorimotor Technologies.Journal of medical Internet research · 2024Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although prolonged exposure (PE) has received the most empirical support of any treatment for post-traumatic stress disorder (PTSD), clinicians are often hesitant to use PE due to beliefs that it is contraindicated for many patients with PTSD. This is especially true for PTSD patients with comorbid problems. Because PTSD has high rates of comorbidity, it is important to consider whether PE is indeed contraindicated for patients with various comorbid problems. Therefore, in this study, we examine the evidence for or against the use of PE with patients with problems that often co-occur with PTSD, including dissociation, borderline personality disorder, psychosis, suicidal behavior and non-suicidal self-injury, substance use disorders, and major depression. It is concluded that PE can be safely and effectively used with patients with these comorbidities, and is often associated with a decrease in PTSD as well as the comorbid problem. In cases with severe comorbidity, however, it is recommended to treat PTSD with PE while providing integrated or concurrent treatment to monitor and address the comorbid problems.
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Registered trials
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