ArticleThe journal of physiological sciences : JPS2012
Autonomic boundary conditions for ventricular fibrillation and their implications for a novel defibrillation technique.
Article in The journal of physiological sciences : JPS, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Article
- Causes and Effects Contributing to Sudden Death in Epilepsy and the Rationale for Prevention and Intervention.Frontiers in neurology · 2020Article
- Proposed Mechanism-Based Risk Stratification and Algorithm to Prevent Sudden Death in Epilepsy.Frontiers in neurology · 2020Review
- Electrophysiological characteristics of the rat azygos vein under electrical pacing and adrenergic stimulation.The journal of physiological sciences : JPS · 2018Article
- An explanation for sudden death in epilepsy (SUDEP).The journal of physiological sciences : JPS · 2018Review
- Autonomic Regulation and Ventricular Arrhythmias.Current treatment options in cardiovascular medicine · 2018Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The sympathetic and parasympathetic divisions of the autonomic nervous system modulate cardiac rhythm and the probability of arrhythmia occurrence. Both increased sympathetic drive and hypoxia increase the likelihood for ventricular fibrillation (VF). Vagus nerve stimulation (VNS) can protect from fatal arrhythmias via cholinergic and nitrergic action. We sought to determine boundary conditions for VF and defibrillation by autonomic manipulations accompanied or not by hypoxic changes in urethane-anesthetized rats. VF was induced with (1) vagotomy, (2) systemic high-dose (>15 mg/kg) isoproterenol, and (3) hypoxemia. When VNS (50 Hz) produced cardiac standstill, it converted every VF episode (59/59). A nitric oxide synthase inhibitor did not reduce VNS efficacy (13/14 episodes converted), but addition of atropine reduced VNS efficacy (11/27 episodes converted). VF can be induced by autonomic derangements only under constrained conditions, including sympathetic over-activation, reduced parasympathetic input, and hypoxemia. VNS can provide an alternative method to defibrillate via its cholinergic action.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.