ReviewBiointerphases2012
Multivariate analysis of ToF-SIMS data from multicomponent systems: the why, when, and how.
Review in Biointerphases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
65 citing papers in PubMed.
- Assessing Acrylic Inks: A Study of Colorants and Lightfastness.ACS omega · 2026Article
- Automated Peak Annotation in Time-of-Flight Secondary Ion Mass Spectrometry via a Physics-Informed Probabilistic Framework.Molecules (Basel, Switzerland) · 2026Article
- Contemporary Techniques and Prospects in Pharmaceutical Tablet Surface Analysis.ACS measurement science au · 2026Article
- Tailored Xenogeneic-Free Polymer Surface Promotes Dynamic Migration of Intestinal Stem Cells.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Developing a Multi-Method Approach for Understanding Cellular Uptake and Biological Response: Investigating Co-Exposure of Macrophage-like Differentiated THP-1 Cells to AlMolecules (Basel, Switzerland) · 2025Article
- Identifying Process Differences with ToF-SIMS: An MVA Decomposition Strategy.Journal of the American Society for Mass Spectrometry · 2024Article
- The Application of a Random Forest Classifier to ToF-SIMS Imaging Data.Journal of the American Society for Mass Spectrometry · 2024Article
- Development of Peptide Identification System for ToF-SIMS Spectra Using Supervised Machine Learning.Journal of the American Society for Mass Spectrometry · 2024Article
- ToF-SIMS evaluation of PEG-related mass peaks and applications in PEG detection in cosmetic products.Scientific reports · 2024Article
- Time-of-Flight Secondary Ion Mass Spectrometry Coupled with Unsupervised Methods for Advanced Saffron Authenticity Screening.Foods (Basel, Switzerland) · 2024Article
- Carotenoids and Intestinal Harmony: Exploring the Link for Health.Foods (Basel, Switzerland) · 2024Article
- ToF-SIMS analysis of ultrathin films and their fragmentation patterns.Journal of vacuum science & technology. A, Vacuum, surfaces, and films : an official journal of the American Vacuum Society · 2024Article
- Secondary Ion Mass Spectral Imaging of Metals and Alloys.Materials (Basel, Switzerland) · 2024Review
- Recent Developments and Application of Mass Spectrometry Imaging in N-Glycosylation Studies: An Overview.Mass spectrometry (Tokyo, Japan) · 2024Review
- Identification of Lithium Compounds on Surfaces of Lithium Metal Anode with Machine-Learning-Assisted Analysis of ToF-SIMS Spectra.ACS applied materials & interfaces · 2023Article
- Mass Spectral Imaging to Map Plant-Microbe Interactions.Microorganisms · 2023Review
- Back to the basics of time-of-flight secondary ion mass spectrometry data analysis of bio-related samples. II. Data processing and display.Biointerphases · 2023Article
- Review of Recent Advances in Gas-Assisted Focused Ion Beam Time-of-Flight Secondary Ion Mass Spectrometry (FIB-TOF-SIMS).Materials (Basel, Switzerland) · 2023Review
- Molecular identification of wines usingFrontiers in chemistry · 2023Article
- Natural Clinoptilolite Nanoparticles Coated with Phosphatidylcholine.Doklady. Biochemistry and biophysics · 2022Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The use of multivariate analysis (MVA) methods in the processing of time-of-flight secondary ion mass spectrometry (ToF-SIMS) data has become increasingly more common. MVA presents a powerful set of tools to aid the user in processing data from complex, multicomponent surfaces such as biological materials and biosensors. When properly used, MVA can help the user identify the major sources of differences within a sample or between samples, determine where certain compounds exist on a sample, or verify the presence of compounds that have been engineered into the surface. Of all the MVA methods, principal component analysis (PCA) is the most commonly used and forms an excellent starting point for the application of many of the other methods employed to process ToF-SIMS data. Herein we discuss the application of PCA and other MVA methods to multicomponent ToF-SIMS data and provide guidelines on their application and use.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.