ArticleClinical oral investigations2013
Inflammatory cells of immunosuppressive phenotypes in oral lichen planus have a proinflammatory pattern of expression and are associated with clinical parameters.
Article in Clinical oral investigations, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Macrophages and the immune microenvironment in OPMDs: a systematic review of the literature.Frontiers in oral health · 2025Pooled it
- A Systematic Review of Interleukin-17 in Oral Lichen Planus: From Etiopathogenesis to Treatment.Clinical medicine & research · 2023Pooled it
- Does oral lichen planus aggravate the state of periodontal disease? A systematic review and meta-analysis.Clinical oral investigations · 2022Pooled it
- Potential different immune phenotypes of macrophages in oral lichen planus by integrating immunofluorescence double staining and single-cell RNA sequencing.Journal of dental sciences · 2024Article
- Salivary metabolomics in patients with oral lichen planus: a preliminary study based on NMR spectroscopy.Clinical oral investigations · 2024Article
- The potential roles of Th17 cells in the pathogenesis of oral lichen planus.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023Review
- Lymphocyte and CD62E expression in lichen planus and lichenoid reaction.BMC oral health · 2022Article
- Chronic atrophic gastritis aggravate chronic periodontitis with Helicobacter pylori infection and CD4+Th cytokines infiltration.Histology and histopathology · 2020Article
- Artemisinin and its derivatives: a potential therapeutic approach for oral lichen planus.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2019Review
- Oral lichen-planus-associated fibroblasts acquire myofibroblast characteristics and secrete pro-inflammatory cytokines in response to Porphyromonas gingivalis lipopolysaccharide stimulation.BMC oral health · 2018Article
- Oral lichen planus may enhance the expression of Th17-associated cytokines in local lesions of chronic periodontitis.Clinical oral investigations · 2014Article
- Cutaneous and mucosal lichen planus: a comprehensive review of clinical subtypes, risk factors, diagnosis, and prognosis.TheScientificWorldJournal · 2014Review
- Myeloid derived suppressor cells in physiological and pathological conditions: the good, the bad, and the ugly.Immunologic research · 2013Review
- Interaction between oral lichen planus and chronic periodontitis with Th17-associated cytokines in serum.Inflammation · 2013Article
- Role of Forkhead box protein 3 in the pathogenesis of oral lichen planus: A systematic review.Journal of oral and maxillofacial pathology : JOMFPReview
- Immunohistochemical expression of M1 and M2 macrophages in oral lichen planus and oral squamous cell carcinoma using CD68 and CD163: A comparative study.Journal of oral and maxillofacial pathology : JOMFPArticle
- Oxidative Stress and Oral Mucosal Diseases: An Overview.In vivo (Athens, Greece)Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesWe sought to investigate the expression of cells with immunosuppressive/protumorigenic phenotypes in oral lichen planus (OLP), such as M2-tumor-associated macrophages (TAM2), myeloid-derived suppressive cells (MDSCs), and regulatory T cells (Tregs) in association with clinical parameters. MATERIALS AND
methodsCases of hyperkeratotic (HK)-OLP (n = 23) and erosive (E)-OLP (n = 26) were immunohistochemically stained to determine the percentages of CD163-TAM2, CD80-MDSCs, and FOXP3-Tregs of proinflammatory CD121a-Th17, CD4 and CD8 lymphocytes, and of cells positive for nuclear factor kappa B (NF-κB) and transforming growth factor beta. Clinical parameters included symptoms, treatment approach, treatment response, and others.
resultsThe inflammatory infiltrate in HK-OLP and E-OLP contained immunosuppressive cells; however, their pattern of expression was compatible with a proinflammatory response [membranous CD163-TAM2 staining (not extracellular), CD80+ lymphocytes (not macrophages), and a few Tregs]. The presence of CD4+, CD8+, and CD121a+ T lymphocytes was extensive. TAM2 were more frequent in E-OLP than in HK-OLP (P = 0.017). A higher frequency of CD80+ lymphocytes was associated with partial to no response to treatment (P = 0.028). Nuclear expression of NF-κB in the inflammatory cells was absent.
conclusionsThe pattern of expression of the immunosuppressive cells, together with numerous CD4+, CD8+, and Th17-CD121a+ lymphocytes, suggest an extensive proinflammatory response rather than an immunosuppressive/protumorigenic response. CLINICAL RELEVANCE: The frequency of selective types of inflammatory cells calls for individual profile analyses of inflammatory infiltrates and individually adjusted treatment.
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