ArticleMolecular systems biology2012
Quantitative measurement of allele-specific protein expression in a diploid yeast hybrid by LC-MS.
Article in Molecular systems biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- Normal Alpha-1-Antitrypsin Variants Display in Serum Allele-Specific Protein Levels.Journal of proteome research · 2023Article
- Article
- SMAP is a pipeline for sample matching in proteogenomics.Nature communications · 2022Article
- Genetic architecture of protein expression and its regulation in the mouse brain.BMC genomics · 2021Article
- Genome and transcriptome evolve separately in recently hybridizedCommunications biology · 2019Article
- Determining Allele-Specific Protein Expression (ASPE) Using a Novel Quantitative Concatamer Based Proteomics Method.Journal of proteome research · 2018Article
- Mitochondrial proteomics of the acetic acid - induced programmed cell death response in a highly tolerantMicrobial cell (Graz, Austria) · 2016Article
- Coordinated Evolution of Transcriptional and Post-Transcriptional Regulation for Mitochondrial Functions in Yeast Strains.PloS one · 2016Article
- Extensive allele-specific translational regulation in hybrid mice.Molecular systems biology · 2015Article
- A Systems Approach to Elucidate Heterosis of Protein Abundances in Yeast.Molecular & cellular proteomics : MCP · 2015Article
- Evolution of gene regulation during transcription and translation.Genome biology and evolution · 2015Article
- Methods of integrating data to uncover genotype-phenotype interactions.Nature reviews. Genetics · 2015Review
- Negative feedback buffers effects of regulatory variants.Molecular systems biology · 2015Article
- Decoding neuroproteomics: integrating the genome, translatome and functional anatomy.Nature neuroscience · 2014Review
- Extensive and coordinated control of allele-specific expression by both transcription and translation in Candida albicans.Genome research · 2014Article
- Ribosome profiling reveals post-transcriptional buffering of divergent gene expression in yeast.Genome research · 2014Article
- Evolution at two levels of gene expression in yeast.Genome research · 2014Article
- Large-scale mass spectrometric detection of variant peptides resulting from nonsynonymous nucleotide differences.Journal of proteome research · 2014Article
- Extensive translational regulation of gene expression in an allopolyploid (Glycine dolichocarpa).The Plant cell · 2014Article
- Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Understanding the genetic basis of gene regulatory variation is a key goal of evolutionary and medical genetics. Regulatory variation can act in an allele-specific manner (cis-acting) or it can affect both alleles of a gene (trans-acting). Differential allele-specific expression (ASE), in which the expression of one allele differs from another in a diploid, implies the presence of cis-acting regulatory variation. While microarrays and high-throughput sequencing have enabled genome-wide measurements of transcriptional ASE, methods for measurement of protein ASE (pASE) have lagged far behind. We describe a flexible, accurate, and scalable strategy for measurement of pASE by liquid chromatography-coupled mass spectrometry (LC-MS). We apply this approach to a hybrid between the yeast species Saccharomyces cerevisiae and Saccharomyces bayanus. Our results provide the first analysis of the relative contribution of cis-acting and trans-acting regulatory differences to protein expression divergence between yeast species.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.