ArticleEuropean journal of pediatrics2012
Diagnosis delay in West syndrome: misdiagnosis and consequences.
Article in European journal of pediatrics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 87 citations in OpenAlex.
- Clinical features of Infantile Epileptic Spasms Syndrome: a systematic review.Orphanet journal of rare diseases · 2026Pooled it
- Smartphone videos for infantile epileptic spasms triaging and assessment (VISTA study): Impact of education and standardized clinical history on diagnostic accuracy.Epilepsia open · 2026Article
- Artificial intelligence-assisted detection of epileptic spasms using electroencephalographic-video analysis.Epilepsia · 2026Article
- Prediction of treatment response in infantile epileptic spasms syndrome using EEG phase-amplitude coupling.Epilepsia open · 2026Article
- Long-term outcome in children with infantile epileptic spasms syndrome: a multicenter retrospective study in Korea.Clinical and experimental pediatrics · 2026Article
- Understanding and overcoming delays to pediatric epilepsy surgery: a scoping review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Article
- The multiple hit model of infantile and epileptic spasms: The 2025 update.Epilepsia open · 2025Article
- A model-based cost-effectiveness estimates of hormonal therapy in Indian children with infantile epileptic spasms syndrome.Epilepsia open · 2025Observational
- Detection of epileptic spasms using foundational AI and smartphone videos.NPJ digital medicine · 2025Article
- Predictive model for initial response to first-line treatment in children with infantile epileptic spasms syndrome.Italian journal of pediatrics · 2025Article
- Efficacy and tolerability of celastrol and edaravone in the multiple-hit rat model of infantile spasms.Epilepsy & behavior : E&B · 2025Article
- Exhaustive clinical examination of etiology and initial response to first-line treatment in 577 children with infantile epileptic spasm syndrome children: A 5-year retrospective observational study.Annals of clinical and translational neurology · 2024Observational
- Timing the clinical onset of epileptic spasms in infantile epileptic spasms syndrome: A tertiary health center's experience.Epilepsia · 2024Article
- Clinical characteristics and diagnoses of 1213 children referred to a first seizure clinic.Epilepsia open · 2024Article
- Revisiting the concept of drug-resistant epilepsy: A TASK1 report of the ILAE/AES Joint Translational Task Force.Epilepsia · 2023Article
- EEG biomarkers for the diagnosis and treatment of infantile spasms.Frontiers in neurology · 2022Review
- Automated preprocessing and phase-amplitude coupling analysis of scalp EEG discriminates infantile spasms from controls during wakefulness.Epilepsy research · 2021Article
- Antiepileptogenic effects of rapamycin in a model of infantile spasms due to structural lesions.Epilepsia · 2021Article
- Impact of predictive, preventive and precision medicine strategies in epilepsy.Nature reviews. Neurology · 2020Review
- Radiprodil, a NR2B negative allosteric modulator, from bench to bedside in infantile spasm syndrome.Annals of clinical and translational neurology · 2020Article
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
West syndrome or infantile spasms is one of the most frequent epileptic syndromes in the first year of life. The clinical symptoms of infantile spasms are very different than any other type of seizure because of both the absence of paroxysmal motor phenomena (i.e., as in a convulsion) and the lack of significant duration of loss of consciousness (i.e., as in absence epilepsy). Infantile spasms may lead to misdiagnosis by pediatricians and other primary care providers. We assessed the missed diagnoses prior to the diagnosis of infantile spasms. We hypothesized that a delay in treatment may have consequences on neurologic outcome. We conducted a multicenter, retrospective, observational study to evaluate occurrence of misdiagnosis and its possible consequences. We performed a multivariate analysis to evaluate the risk for the outcome 2 years after the diagnosis of infantile spasms. We included 83 infants over a 5-year period. The majority of consulted physicians (301 of 362) did not suggest any specific diagnosis while the others suggested gastroesophageal reflux (7 %), constipation (7 %), or colitis (3 %). Results indicated that a poor outcome was related to a delay in diagnosis, which was observed regardless of the existence of cognitive involvement prior to the start of infantile spasms (Relative Risk: RR 12.08 [1.52-96.3]). These results highlight the importance of making an early diagnosis of infantile spasms.
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