Evidence map›Paper›PMID 22892856›Full record

ArticleKidney international2012

Role changes of β-catenin in kidney injury and repair.

Jianping Peng, Zheng Dong

Open access · bronzeAbstract readComment
PubMed Publisher
In one paragraph

Article in Kidney international, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Sustained Activation of Wnt/β-Catenin Signaling Drives AKI to CKD Progression.Journal of the American Society of Nephrology : JASN · 2016
    Article
  5. Wnt/β-catenin signaling in kidney injury and repair: a double-edged sword.Laboratory investigation; a journal of technical methods and pathology · 2016
    Review
  6. Review
  7. Delayed administration of a single dose of lithium promotes recovery from AKI.Journal of the American Society of Nephrology : JASN · 2014
    Article
  8. Roles of adaptor proteins in podocyte biology.World journal of nephrology · 2013
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Jianping Peng
Zheng Dong
Charlie Norwood VA Medical Center · USWuhan University · CN

Funding

DNA methylation in kidney repair after ischemic AKIR01DK058831 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT · PI DONG, ZHENG · 2001 to 2025
$7.5M
Kidney Injury by Cisplatin and Renoprotective Strategies.R01DK087843 · NIDDK · AUGUSTA UNIVERSITY · PI DONG, ZHENG · 2010 to 2025
$5.8M
NIDDK NIH HHS R01 DK058831NIDDK NIH HHS R01 DK087843
6 · The paper itself

Abstract

Using conditional knockout models, Zhou et al. firmly establish a renoprotective role of β-catenin in acute kidney injury. Although β-catenin is protective at the injury phase, whether it helps kidney repair remains in question. In a renal cell scratch model, β-catenin suppresses wound healing. Moreover, continuous activation of β-catenin may lead to renal fibrosis. Further investigation should elucidate the distinct roles played by β-catenin and related signaling in kidney injury, repair, and fibrosis.

Indexed as

DoxorubicinSignal TransductionAnimalsClass I Phosphatidylinositol 3-KinasesGlomerulosclerosis, Focal SegmentalKidneyMaleProteinuriaSmad3 Protein1-phosphatidylinositol 3-kinase p110 subunit, mouseClass I Phosphatidylinositol 3-KinasesDoxorubicinSmad3 ProteinSmad3 protein, mouse

Identifiers

PMID22892856
OpenAlexW2079108159

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.