Evidence map›Paper›PMID 22892738›Full record

ArticleJournal of endodontics2012

Analysis of the contribution of nonresident progenitor cells and hematopoietic cells to reparative dentinogenesis using parabiosis model in mice.

Marcos Frozoni, Alexandre Augusto Zaia, Sergio Roberto Peres Line, Mina Mina

Abstract read
In one paragraph

Article in Journal of endodontics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 21 citations in OpenAlex.

  1. Direct pulp capping with autologous bone marrow derived stem cells in dogs.Veterinary research forum : an international quarterly journal · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Marcos FrozoniDepartment of Restorative Dentistry, Division of Endodontics, Dental School of Piracicaba, State University of Campinas, São Paulo, São Paulo, Brazil. marcos.rfrozoni@terra.com.br
Alexandre Augusto Zaia
Sergio Roberto Peres Line
Mina Mina
UConn Health · USUniversidade Estadual de Campinas (UNICAMP) · BR

Funding

Analysis of GFP Transgenes in Odontoblast in DifferentiationR01DE016689 · NIDCR · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI MINA, MINA · 2006 to 2016
$3.3M
Analysis of GFP Transgenes in Odontoblast in DifferentiationR56DE016689 · NIDCR · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI MINA, MINA · 2021 to 2021
$369k
NIDCR NIH HHS DE016689NIDCR NIH HHS R01 DE016689NIDCR NIH HHS R56 DE016689
6 · The paper itself

Abstract

introductionThe aim of this study was to analyze the contribution of nonresident progenitor/stem cells and hematopoietic cells to reparative dentinogenesis.

methodsParabiosis was established between C57BL/6-TgN(ACTbEGFP)10sb/J transgenic mice (GFP+) and C57BL/6 wild-type mice (GFP-) to ensure blood cross-circulation between animals. Reparative dentinogenesis was stimulated by pulp exposures and capping on the first maxillary molar in the GFP- mice. Histologic sections of injured molars from GFP- mice were analyzed by epifluorescence microscopy to examine the contributions of GFP+ cells (nonresident progenitor cells and hematopoietic cells originating from GFP+ mice) to reparative dentinogenesis.

resultsGFP+ cells were detected in close association with reparative dentin formed at the site of pulp exposure in the maxillary first molars of the GFP- mice.

conclusionsThe present study suggests the participation of the nonresident progenitor cells and hematopoietic cells in reparative dentinogenesis.

Indexed as

Acid PhosphataseAluminum CompoundsAnimalsBiomarkersCalcium CompoundsComposite ResinsCross CirculationDental MaterialsDental Pulp CappingDental Pulp ExposureDentinogenesisDentin, SecondaryDrug CombinationsFlow CytometryFluorescent DyesGreen Fluorescent ProteinsAcid PhosphataseAluminum CompoundsBiomarkersCalcium CompoundsClearfil SE BondComposite ResinsDental MaterialsDrug Combinationsenhanced green fluorescent proteinFluorescent DyesGreen Fluorescent ProteinsIsoenzymesmineral trioxide aggregateOxidesPulp Capping and Pulpectomy AgentsResin CementsSilicatesSilicon DioxideTartrate-Resistant Acid PhosphataseZ100 composite resinZirconium

Identifiers

PMID22892738
PMCPMC3745019
OpenAlexW2037685372

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.