Evidence map›Paper›PMID 22892717›Full record

ArticleTranslational psychiatry2012

Associations between LSAMP gene polymorphisms and major depressive disorder and panic disorder.

K Koido, T Traks, R Balõtšev, T Eller, A Must, S Koks, E Maron, I Tõru, J Shlik, V Vasar and 1 more

Open access · goldAbstract read
In one paragraph

Article in Translational psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 6 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 6 syntheses or guidelines pooled it, 60 citations in OpenAlex.

  1. Pooled it
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  6. Pooled it
  7. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

K KoidoDepartment of Physiology, University of Tartu, Tartu, Estonia. kati.koido@ut.ee
T Traks
R Balõtšev
T Eller
A Must
S Koks
E Maron
I Tõru
J Shlik
V Vasar
E Vasar
University of Tartu · EEImperial College London · GBUniversity of Ottawa · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The purpose of this case-control genetic association study was to explore potential relationships between polymorphisms in the limbic system-associated membrane protein (LSAMP) gene and mood and anxiety disorders. A total of 21 single-nucleotide polymorphisms (SNPs) from the LSAMP gene were analyzed in 591 unrelated patients with the diagnoses of major depressive disorder (MDD) or panic disorder (PD) and in 384 healthy control subjects. The results showed a strong association between LSAMP SNPs and MDD, and a suggestive association between LSAMP SNPs and PD. This is the first evidence of a possible role of LSAMP gene in mood and anxiety disorders in humans.

Indexed as

AdolescentAdultAgedAllelesCase-Control StudiesCell Adhesion Molecules, NeuronalEstoniaFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeGPI-Linked ProteinsHaplotypesHumansMajor Depressive DisorderMaleCell Adhesion Molecules, NeuronalGPI-Linked Proteinslimbic system-associated membrane protein

Identifiers

PMID22892717
PMCPMC3432189
OpenAlexW2001143957

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.