ReviewCellular and molecular life sciences : CMLS2013
Show me your license, please: deregulation of centriole duplication mechanisms that promote amplification.
Review in Cellular and molecular life sciences : CMLS, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 40 citations in OpenAlex.
- GPER1 links estrogens to centrosome amplification and chromosomal instability in human colon cells.Life science alliance · 2023Article
- MPS1 is involved in the HPV16-E7-mediated centrosomes amplification.Cell division · 2021Article
- Centrosome dysfunction: a link between senescence and tumor immunity.Signal transduction and targeted therapy · 2020Review
- CEP135 isoform dysregulation promotes centrosome amplification in breast cancer cells.Molecular biology of the cell · 2019Article
- A method of quantifying centrosomes at the single-cell level in human normal and cancer tissue.Molecular biology of the cell · 2019Article
- Divide Precisely and Proliferate Safely: Lessons From Budding Yeast.Frontiers in genetics · 2018Article
- Centrosome amplification: a suspect in breast cancer and racial disparities.Endocrine-related cancer · 2017Review
- Regulation of the centrosome cycle.Molecular & cellular oncology · 2016Review
- Centrosomes in the DNA damage response--the hub outside the centre.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2016Review
- FANCA safeguards interphase and mitosis during hematopoiesis in vivo.Experimental hematology · 2015Article
- Centriole biogenesis and function in multiciliated cells.Methods in cell biology · 2015Article
- Causes and consequences of centrosome abnormalities in cancer.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- Exploring the evolutionary history of centrosomes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- Mitotic spindle multipolarity without centrosome amplification.Nature cell biology · 2014Review
- PIPKIγ targets to the centrosome and restrains centriole duplication.Journal of cell science · 2014Article
- The Toxoplasma gondii calcium-dependent protein kinase 7 is involved in early steps of parasite division and is crucial for parasite survival.Cellular microbiology · 2014Article
- Nek2 and Plk4: prognostic markers, drivers of breast tumorigenesis and drug resistance.Frontiers in bioscience (Landmark edition) · 2014Review
- Article
- An integrated overview of spatiotemporal organization and regulation in mitosis in terms of the proteins in the functional supercomplexes.Frontiers in microbiology · 2014Review
- Molecular and cellular basis of autosomal recessive primary microcephaly.BioMed research international · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Centrosomes are organelles involved in generating and organizing the interphase microtubule cytoskeleton, mitotic spindles and cilia. At the centrosome core are a pair of centrioles, structures that act as the duplicating elements of this organelle. Centrioles function to recruit and organize pericentriolar material which nucleates microtubules. While centrioles are relatively simple in construction, the mechanics of centriole biogenesis remain an important yet poorly understood process. More mysterious still are the regulatory mechanisms that oversee centriole assembly. The fidelity of centriole duplication is critical as defects in either the assembly or number of centrioles promote aneuploidy, primary microcephaly, birth defects, ciliopathies and tumorigenesis. In addition, some pathogens employ mechanisms to promote centriole overduplication to the detriment of the host cell. This review summarizes our current understanding of this important topic, highlighting the need for further study if new therapeutics are to be developed to treat diseases arising from defects of centrosome duplication.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.