ArticleSchizophrenia bulletin2013
Cortex morphology in first-episode psychosis patients with neurological soft signs.
Article in Schizophrenia bulletin, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Neurological soft signs are not "soft" in brain structure and functional networks: evidence from ALE meta-analysis.Schizophrenia bulletin · 2014Pooled it
- The presentation of dermatoglyphic abnormalities in schizophrenia: a meta-analytic review.Schizophrenia research · 2012Pooled it
- Replicable subcortical alterations linked to neurological soft signs in schizophrenia spectrum disorders.Psychological medicine · 2026Article
- Factor Analysis of the Neurological Evaluation Scale (NES) and Corresponding Brain Function and Structures.International journal of methods in psychiatric research · 2026Article
- Schizophrenia Following Early Adolescence Prodrome: A Neurodevelopmental Subtype With Autism-like Sensorimotor and Social Cognition Deficits.Schizophrenia bulletin · 2025Article
- Neurological Soft Signs in Type I Bipolar Disorder and Bipolar Spectrum Patients and Their Unaffected First-Degree Relatives: A Cross-Sectional Study.Health science reports · 2025Article
- A tablet-based quantitative assessment of manual dexterity for detection of early psychosis.Frontiers in psychiatry · 2023Article
- Markers of Schizophrenia-A Critical Narrative Update.Journal of clinical medicine · 2022Review
- The neural substrates of neurological soft signs in schizophrenia: a systematic review.Schizophrenia (Heidelberg, Germany) · 2022Review
- Neurological Soft Signs Are Associated With Altered White Matter in Patients With Schizophrenia.Schizophrenia bulletin · 2022Article
- Intrinsic neural network dynamics in catatonia.Human brain mapping · 2021Article
- Neurological Soft Signs Predict Auditory Verbal Hallucinations in Patients With Schizophrenia.Schizophrenia bulletin · 2021Article
- Neurological Soft Signs (NSS) in Census-Based, Decade-Adjusted Healthy Adults, 20 to >70 Years of Age.Frontiers in psychiatry · 2021Article
- Review
- Multiparametric mapping of white matter microstructure in catatonia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Neurological Soft Signs and Brain Network Abnormalities in Schizophrenia.Schizophrenia bulletin · 2020Article
- Imaging local genetic influences on cortical folding.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Deviations in early hippocampus development contribute to visual hallucinations in schizophrenia.Translational psychiatry · 2020Article
- Multimodal Magnetic Resonance Imaging Data Fusion Reveals Distinct Patterns of Abnormal Brain Structure and Function in Catatonia.Schizophrenia bulletin · 2020Article
- Impaired attentional modulation of sensorimotor control and cortical excitability in schizophrenia.Brain : a journal of neurology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Schizophrenia is a complex brain disorder associated with numerous etiological factors and pathophysiological pathways leading to multiple clinical outcomes. Compelling evidence suggests that deviations in neurodevelopmental processes are a major risk factor of schizophrenia. The identification of patients with high neurodevelopmental deviance is an important issue as it could help to identify homogeneous subgroups of patients with similar pathophysiological pathways, a key step to decipher the etiology of this complex condition. Several clinical arguments suggest that schizophrenia patients with Neurological Soft Signs (NSS)--ie, observable defects in motor coordination, motor integration, and sensory integration--would have high neurodevelopmental deviance. Based on the analysis of magnetic resonance imaging of 44 first-episode psychosis patients, we compared the cortex morphology, a marker of brain development, in patients with NSS vs patients with nonsignificant NSS. The cortex morphology was automatically assessed from three-dimensional global sulcal index (g-SI, the ratio between total sulcal area and outer cortex area) and regional sulcal indexes (r-SI, the ratio between the area of pooled labeled sulci and the total outer cortex area). Patients with NSS were found to have a lower g-SI in both hemispheres and a lower r-SI in left dorsolateral prefrontal and right lateral occipital cortices. Exploratory analyses revealed correlations between NSS dimensions and r-SI in distinct cortical areas, including dorsolateral and medial prefrontal cortices, lateral temporal, occipital, superior parietal, and medial parieto-occipital cortices. These findings provide evidence of distinct neurodevelopmental pathways in patients with NSS as compared with patients with nonsignificant NSS.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.