ArticleSchizophrenia research2012
Alterations in brain structures underlying language function in young adults at high familial risk for schizophrenia.
Article in Schizophrenia research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Intelligence, educational attainment, and brain structure in those at familial high-risk for schizophrenia or bipolar disorder.Human brain mapping · 2022Pooled it
- Hippocampal subregion abnormalities in schizophrenia: A systematic review of structural and physiological imaging studies.Neuropsychopharmacology reports · 2018Pooled it
- Intensive Auditory Cognitive Training Improves Verbal Memory in Adolescents and Young Adults at Clinical High Risk for Psychosis.Schizophrenia bulletin · 2016Trial
- Language Network Dysfunction and Formal Thought Disorder in Schizophrenia.Schizophrenia bulletin · 2023Review
- Disembodiment and Language in Schizophrenia: An Integrated Psychopathological and Evolutionary Perspective.Schizophrenia bulletin · 2023Article
- Mendelian randomization analyses support causal relationships between brain imaging-derived phenotypes and risk of psychiatric disorders.Nature neuroscience · 2022Article
- Historical pursuits of the language pathway hypothesis of schizophrenia.NPJ schizophrenia · 2021Article
- What a Clinician Should Know About the Neurobiology of Schizophrenia: A Historical Perspective to Current Understanding.Focus (American Psychiatric Publishing) · 2020Article
- Psychotic-like experiences, polygenic risk scores for schizophrenia, and structural properties of the salience, default mode, and central-executive networks in healthy participants from UK Biobank.Translational psychiatry · 2020Article
- Aberrant attentive and inattentive brain activity to auditory negative words, and its relation to persecutory delusion in patients with schizophrenia.Neuropsychiatric disease and treatment · 2019Article
- Baseline connectome modular abnormalities in the childhood phase of a longitudinal study on individuals with chromosome 22q11.2 deletion syndrome.Human brain mapping · 2018Article
- Familial and environmental influences on brain volumes in twins with schizophrenia.Journal of psychiatry & neuroscience : JPN · 2017Article
- The Arcuate Fasciculus Network and Verbal Deficits in Psychosis.Translational neuroscience · 2017Article
- Diffusion tensor imaging in first degree relatives of schizophrenia and bipolar disorder patients.Schizophrenia research · 2015Review
- Hippocampal volume is reduced in schizophrenia and schizoaffective disorder but not in psychotic bipolar I disorder demonstrated by both manual tracing and automated parcellation (FreeSurfer).Schizophrenia bulletin · 2015Article
- Neural disruption to theory of mind predicts daily social functioning in individuals at familial high-risk for schizophrenia.Social cognitive and affective neuroscience · 2014Article
- The relationship between default mode network connectivity and social functioning in individuals at familial high-risk for schizophrenia.Schizophrenia research · 2014Article
- The XY gene hypothesis of psychosis: origins and current status.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2013Review
- Gray matter alterations in schizophrenia high-risk youth and early-onset schizophrenia: a review of structural MRI findings.Child and adolescent psychiatric clinics of North America · 2013Review
- Aberrant interference of auditory negative words on attention in patients with schizophrenia.PloS one · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
introductionNeuroanatomical and cognitive alterations typical of schizophrenia (SZ) patients are observed to a lesser extent in their adolescent and adult first-degree relatives, likely reflecting neurodevelopmental abnormalities associated with genetic risk for the illness. The anatomical pathways for language are hypothesized to be abnormal and to underlie the positive symptoms of schizophrenia. Examining non-psychotic relatives at high familial risk (FHR) for schizophrenia may clarify if these deficits represent trait markers associated with genetic vulnerability, rather than specific markers resulting from the pathological process underlying schizophrenia.
methodsT1 MRI scans from a 3T Siemens scanner of young adult FHR subjects (N=46) and controls with no family history of illness (i.e. at low genetic risk LRC; N=31) were processed using FreeSurfer 5.0. We explored volumetric and lateralization alterations in regions associated with language processing. An extensive neuropsychological battery of language measures was administered.
resultsNo significant differences were observed between groups on any language measures. Controlling intracranial volume, significantly smaller left pars triangularis (PT) (p<0.01) and right pars orbitalis (PO) (p<0.01) volumes and reversal of the L>R pars orbitalis (p<0.001) lateralization were observed in FHR subjects. In addition, the L pars triangularis and R pars orbitalis correlated with performance on tests of linguistic function in the FHR group.
conclusionsReduced volume and reversed structural asymmetry in language-related regions hypothesized to be altered in SZ are also found in first degree relatives at FHR, despite normal language performance. To clarify if these findings are endophenotypes for Sz, future studies would need to be performed of ill and well family members no longer within the age range of risk for illness to show these deficits segregate with schizophrenia within families. Moreover, measures of complex language need to be studied to determine if FHR individuals manifest impairments in some aspects of language function.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.