ArticleBMC cancer2012
Survival in patients with stage IV noncardia gastric cancer - the influence of DNA ploidy and Helicobacter pylori infection.
Article in BMC cancer, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Positive H. pylori status predicts better prognosis of non-cardiac gastric cancer patients: results from cohort study and meta-analysis.BMC cancer · 2022Pooled it
- Prognostic value of DNA aneuploidy in gastric cancer: a meta-analysis of 3449 cases.BMC cancer · 2019Pooled it
- Protective role of Helicobacter pylori infection in prognosis of gastric cancer: evidence from 2,454 patients with gastric cancer.PloS one · 2013Pooled it
- Survival of gastric cancer patients based on pathologic and demographic characteristics in Mazandaran between 2007 and 2013.Gastroenterology and hepatology from bed to bench · 2019Article
- Activation of CD3Cancer biology & therapy · 2019Article
- PositiveOncotarget · 2017Article
- Effect of Helicobacter pylori infection on outcomes in resected gastric and gastroesophageal junction cancer.Journal of gastrointestinal oncology · 2017Article
- The Prognostic Influence of BRAF Mutation and other Molecular, Clinical and Laboratory Parameters in Stage IV Colorectal Cancer.Pathology oncology research : POR · 2016Article
- The Effect of Helicobacter pylori on Gastric Cancer Treated with Adjuvant Chemotherapy After Curative Resection.The Indian journal of surgery · 2015Article
- Serum Helicobacter pylori NapA antibody as a potential biomarker for gastric cancer.Scientific reports · 2014Article
- CRM1 is a novel independent prognostic factor for the poor prognosis of gastric carcinomas.Medical oncology (Northwood, London, England) · 2013Article
- Factors Influencing Survival in Stage IV Colorectal Cancer: The Influence of DNA Ploidy.ISRN gastroenterology · 2013Article
- Clinical Influence of Ploidy and Cancer Stem Cells and Other Parameters in Stage IV Colorectal Cancer.In vivo (Athens, Greece)Article
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPalliative surgery followed by postoperative chemotherapy is a challenging approach in the treatment of stage IV gastric cancer yet patients must be carefully selected on the basis of likely clinical benefit.
methodsThe records of 218 patients with histological diagnosis of gastric adenocarcinoma who underwent palliative surgery followed by postoperative chemotherapy were retrospectively reviewed. Twelve potential prognostic variables including tumour DNA index and serum IgG anti- Helicobacter pylori (HP) antibodies were evaluated for their influence on overall survival by multivariate analysis.
resultsThe median survival was 13.25 months [95% Confidence Interval (CI) 12.00, 14.50]. Three factors were found to have an independent effect on survival: performance status (PS) [PS 60-70 vs. 90-100 Hazard Ratio (HR) 1.676; CI 1.171-2.398, p = 0.005], liver metastases (HR 1.745; CI 1.318-2.310, p < 0.001), and DNA Index as assessed by Image cytometry (2.2-3.6 vs. >3.6 HR 3.059; CI 2.185-4.283, p < 0.001 and <2.2 vs. >3.6 HR; 4.207 CI 2.751-6.433 <0.001). HP infection had no statistically significant effect on survival by either univariate or multivariate analysis.
conclusionPoor pre-treatment PS, the presence of liver metastasis and high DNA Index were identified factors associated with adverse survival outcome in patients with Stage IV gastric cancer treated with palliative gastrectomy and postoperative chemotherapy. HP infection had no influence on survival of these patients.
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