ArticleBiochemistry2012
A picomolar transition state analogue inhibitor of MTAN as a specific antibiotic for Helicobacter pylori.
Article in Biochemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Clodronic Acid has Strong Inhibitory Interactions with the Urease Enzyme ofCurrent computer-aided drug design · 2024Article
- Residence Times for Femtomolar and Picomolar Inhibitors of MTANs.Biochemistry · 2023Article
- MAT Gain of Activity Mutation inACS infectious diseases · 2023Article
- Inhibition of the futalosine pathway for menaquinone biosynthesis suppresses Chlamydia trachomatis infection.FEBS letters · 2021Article
- Identification of pulvomycin as an inhibitor of the futalosine pathway.The Journal of antibiotics · 2021Article
- Inverse heavy enzyme isotope effects in methylthioadenosine nucleosidases.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Aminofutalosine Deaminase in the Menaquinone Pathway ofBiochemistry · 2021Article
- Identification of immucillin analogue natural compounds to inhibitIn silico pharmacology · 2021Article
- Helicobacter pylori treatment in the post-antibiotics era-searching for new drug targets.Applied microbiology and biotechnology · 2020Review
- Transition State Analogues Enhanced by Fragment-Based Structural Analysis: Bacterial Methylthioadenosine Nucleosidases.Biochemistry · 2020Article
- Characterization of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidases from Borrelia burgdorferi: Antibiotic targets for Lyme disease.Biochimica et biophysica acta. General subjects · 2020Article
- Selective Inhibitors of Helicobacter pylori Methylthioadenosine Nucleosidase and Human Methylthioadenosine Phosphorylase.Journal of medicinal chemistry · 2019Article
- Antibacterial Strategy againstACS medicinal chemistry letters · 2019Article
- Searching for potent and specific antibiotics against pathogenic Helicobacter and Campylobacter strains.Journal of industrial microbiology & biotechnology · 2019Review
- Enzymatic Transition States and Drug Design.Chemical reviews · 2018Review
- Aplasmomycin and boromycin are specific inhibitors of the futalosine pathway.The Journal of antibiotics · 2018Article
- Immucillins in Infectious Diseases.ACS infectious diseases · 2018Review
- Transition State Analogue Inhibitors of 5'-Deoxyadenosine/5'-Methylthioadenosine Nucleosidase from Mycobacterium tuberculosis.Biochemistry · 2017Article
- Efficient diastereoselective synthesis of a new class of azanucleosides: 2'-homoazanucleosides.Tetrahedron · 2017Article
- Identification of tirandamycins as specific inhibitors of the futalosine pathway.The Journal of antibiotics · 2017Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Campylobacter and Helicobacter species express a 6-amino-6-deoxyfutalosine N-ribosylhydrolase (HpMTAN) proposed to function in menaquinone synthesis. BuT-DADMe-ImmA is a 36 pM transition state analogue of HpMTAN, and the crystal structure of the enzyme-inhibitor complex reveals the mechanism of inhibition. BuT-DADMe-ImmA has a MIC(90) value of <8 ng/mL for Helicobacter pylori growth but does not cause growth arrest in other common clinical pathogens, thus demonstrating potential as an H. pylori-specific antibiotic.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.