ArticleProceedings of the National Academy of Sciences of the United States of America2012
Telomere fusions in early human breast carcinoma.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 52 citations in OpenAlex.
- Conception and Concern: A Review of Breast Cancer Risk in Assisted Reproductive Technology.International journal of biological sciences · 2025Review
- The Role of Molecular and Cellular Aging Pathways on Age-Related Hearing Loss.International journal of molecular sciences · 2024Review
- The ALT pathway generates telomere fusions that can be detected in the blood of cancer patients.Nature communications · 2024Article
- Kinesin Family Member C1 (KIFC1/HSET): A Potential Actionable Biomarker of Early Stage Breast Tumorigenesis and Progression of High-Risk Lesions.Journal of personalized medicine · 2021Review
- Mechanisms and Regulation of Cellular Senescence.International journal of molecular sciences · 2021Review
- Regulation of Gene Expression by Telomere Position Effect.International journal of molecular sciences · 2021Review
- Progesterone and Breast Cancer.Endocrine reviews · 2020Review
- Article
- Stem cells, immortality, and the evolution of metastatic properties in breast cancer: telomere maintenance mechanisms and metastatic evolution.Journal of cancer metastasis and treatment · 2019Article
- Ongoing human chromosome end extension revealed by analysis of BioNano and nanopore data.Scientific reports · 2018Article
- Generation of Immortalised But Unstable Cells after hTERT Introduction in Telomere-Compromised and p53-Deficient vHMECs.International journal of molecular sciences · 2018Article
- Acute telomere deprotection prevents ongoing BFB cycles and rampant instability in p16Oncotarget · 2018Article
- Development of a New Monochrome Multiplex qPCR Method for Relative Telomere Length Measurement in Cancer.Neoplasia (New York, N.Y.) · 2018Article
- Review
- Telomeres: Implications for Cancer Development.International journal of molecular sciences · 2018Review
- Simple Detection of Telomere Fusions in Pancreatic Cancer, Intraductal Papillary Mucinous Neoplasm, and Pancreatic Cyst Fluid.The Journal of molecular diagnostics : JMD · 2018Article
- Telomere DNA damage signaling regulates cancer stem cell evolution, epithelial mesenchymal transition, and metastasis.Oncotarget · 2017Article
- Telomeres in cancer: tumour suppression and genome instability.Nature reviews. Molecular cell biology · 2017Review
- Article
- Breast primary epithelial cells that escape p16-dependent stasis enter a telomere-driven crisis state.Breast cancer research : BCR · 2016Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several lines of evidence suggest that defects in telomere maintenance play a significant role in the initiation of genomic instability during carcinogenesis. Although the general concept of defective telomere maintenance initiating genomic instability has been acknowledged, there remains a critical gap in the direct evidence of telomere dysfunction in human solid tumors. To address this topic, we devised a multiplex PCR-based assay, termed TAR (telomere-associated repeat) fusion PCR, to detect and analyze chromosome end-to-end associations (telomere fusions) within human breast tumor tissue. Using TAR fusion PCR, we found that human breast lesions, but not normal breast tissues from healthy volunteers, contained telomere fusions. Telomere fusions were detected at similar frequencies during early ductal carcinoma in situ and in the later invasive ductal carcinoma stage. Our results provide direct evidence that telomere fusions are present in human breast tumor tissue and suggest that telomere dysfunction may be an important component of the genomic instability observed in this cancer. Development of this robust method that allows identification of these genetic aberrations (telomere fusions) is anticipated to be a valuable tool for dissecting mechanisms of telomere dysfunction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.