ArticleProceedings of the National Academy of Sciences of the United States of America2012
Structural investigations of a Podoviridae streptococcus phage C1, implications for the mechanism of viral entry.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Small viruses reveal bidirectional evolution between HK97-fold viruses and encapsulins via procapsids.Nature communications · 2026Article
- Origin, Evolution and Diversity of φ29-like Phages-Review and Bioinformatic Analysis.International journal of molecular sciences · 2024Review
- Article
- A structural dendrogram of the actinobacteriophage major capsid proteins provides important structural insights into the evolution of capsid stability.Structure (London, England : 1993) · 2023Article
- Structure and host specificity ofScience advances · 2022Article
- T7 Phage as an Emerging Nanobiomaterial with Genetically Tunable Target Specificity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Review
- Analysis of intact prophages in genomes ofFrontiers in microbiology · 2022Article
- Predicting the capsid architecture of phages from metagenomic data.Computational and structural biotechnology journal · 2022Article
- Cell wall polysaccharides of Gram positive ovococcoid bacteria and their role as bacteriophage receptors.Computational and structural biotechnology journal · 2021Review
- The Missing Tailed Phages: Prediction of Small Capsid Candidates.Microorganisms · 2020Article
- Structure and genome ejection mechanism ofScience advances · 2019Article
- Artificial bio-nanomachines based on protein needles derived from bacteriophage T4.Biophysical reviews · 2018Review
- Membrane Penetration by Bacterial Viruses.Journal of virology · 2017Review
- Structure and genome release of Twort-like Myoviridae phage with a double-layered baseplate.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Cognition, Information Fields and Hologenomic Entanglement: Evolution in Light and Shadow.Biology · 2016Article
- Cell Walls and the Convergent Evolution of the Viral Envelope.Microbiology and molecular biology reviews : MMBR · 2015Review
- Nature's favorite building block: Deciphering folding and capsid assembly of proteins with the HK97-fold.Virology · 2015Review
- Article
- Molecular architecture of tailed double-stranded DNA phages.Bacteriophage · 2014Review
- An intramolecular chaperone inserted in bacteriophage P22 coat protein mediates its chaperonin-independent folding.The Journal of biological chemistry · 2013Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
The Podoviridae phage C1 was one of the earliest isolated bacteriophages and the first virus documented to be active against streptococci. The icosahedral and asymmetric reconstructions of the virus were calculated using cryo-electron microscopy. The capsid protein has an HK97 fold arranged into a T = 4 icosahedral lattice. The C1 tail is terminated with a ϕ29-like knob, surrounded by a skirt of twelve long appendages with novel morphology. Several C1 structural proteins have been identified, including a candidate for an appendage. The crystal structure of the knob has an N-terminal domain with a fold observed previously in tube forming proteins of Siphoviridae and Myoviridae phages. The structure of C1 suggests the mechanisms by which the virus digests the cell wall and ejects its genome. Although there is little sequence similarity to other phages, conservation of the structural proteins demonstrates a common origin of the head and tail, but more recent evolution of the appendages.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.