Trial reportPediatrics2012
Efficacy of fat-soluble vitamin supplementation in infants with biliary atresia.
Trial report in Pediatrics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 108 citations in OpenAlex.
- Glucocorticosteroids for infants with biliary atresia following Kasai portoenterostomy.The Cochrane database of systematic reviews · 2018Pooled it
- Weekly regimen of vitamin D supplementation is more efficacious than stoss regimen for treatment of vitamin D deficiency in children with chronic liver diseases.European journal of pediatrics · 2018Trial
- Total serum bilirubin predicts fat-soluble vitamin deficiency better than serum bile acids in infants with biliary atresia.Journal of pediatric gastroenterology and nutrition · 2014Trial
- Trial
- Vitamin D Status and Response to Calcifediol Supplementation in Term and Preterm Infants with Cholestasis.Nutrients · 2026Observational
- Review
- Biomarkers in biliary atresia - an elusive promise of predicting outcome.Pediatric research · 2025Article
- Vitamin K deficiency bleeding in children with cholestatic liver disease: a systematic review and meta-analysis.Research and practice in thrombosis and haemostasis · 2025Review
- Late-onset vitamin K deficiency presenting as haemorrhagic shock and severe multi-system organ failure.BMJ case reports · 2024Article
- Treatment of Cholestasis in Infants and Young Children.Current gastroenterology reports · 2023Review
- Determination of Optimal Vitamin D Dosage in Children with Cholestasis.BMC pediatrics · 2023Article
- Article
- Fat-soluble vitamins: updated review of their role and orchestration in human nutrition throughout life cycle with sex differences.Nutrition & metabolism · 2022Review
- Secondary Malnutrition and Nutritional Intervention in Cholestatic Liver Diseases in Infants.Frontiers in nutrition · 2021Review
- METABOLIC AND NUTRITIONAL REPERCUSSIONS OF LIVER DISEASE ON CHILDREN: HOW TO MINIMIZE THEM?Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2021Review
- Fermentable fibers induce rapid macro- and micronutrient depletion in Toll-like receptor 5-deficient mice.American journal of physiology. Gastrointestinal and liver physiology · 2020Article
- Pediatric Cholestasis: Epidemiology, Genetics, Diagnosis, and Current Management.Clinical liver disease · 2020Review
- Pediatric Cholestatic Liver Disease: Review of Bile Acid Metabolism and Discussion of Current and Emerging Therapies.Frontiers in medicine · 2020Review
- Vitamin K deficiency bleeding in an apparently healthy newborn infant: the compelling need for evidence-based recommendation.Italian journal of pediatrics · 2019Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 13 institutions in 1 country.
Funding
Abstract
objectiveCholestasis predisposes to fat-soluble vitamin (FSV) deficiencies. A liquid multiple FSV preparation made with tocopheryl polyethylene glycol-1000 succinate (TPGS) is frequently used in infants with biliary atresia (BA) because of ease of administration and presumed efficacy. In this prospective multicenter study, we assessed the prevalence of FSV deficiency in infants with BA who received this FSV/TPGS preparation.
methodsInfants received FSV/TPGS coadministered with additional vitamin K as routine clinical care in a randomized double-blinded, placebo-controlled trial of corticosteroid therapy after hepatoportoenterostomy (HPE) for BA (identifier NCT 00294684). Levels of FSV, retinol binding protein, total serum lipids, and total bilirubin (TB) were measured 1, 3, and 6 months after HPE.
resultsNinety-two infants with BA were enrolled in this study. Biochemical evidence of FSV insufficiency was common at all time points for vitamin A (29%-36% of patients), vitamin D (21%-37%), vitamin K (10%-22%), and vitamin E (16%-18%). Vitamin levels were inversely correlated with serum TB levels. Biochemical FSV insufficiency was much more common (15%-100% for the different vitamins) in infants whose TB was ≥2 mg/dL. At 3 and 6 months post HPE, only 3 of 24 and 0 of 23 infants, respectively, with TB >2 mg/dL were sufficient in all FSV.
conclusionsBiochemical FSV insufficiency is commonly observed in infants with BA and persistent cholestasis despite administration of a TPGS containing liquid multiple FSV preparation. Individual vitamin supplementation and careful monitoring are warranted in infants with BA, especially those with TB >2 mg/dL.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.