ArticleDiabetes2012
Mitochondrial DNA coding and control region variants as genetic risk factors for type 2 diabetes.
Article in Diabetes, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.
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Who cites it
38 citing papers in PubMed, 2 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- Association of mitochondrial DNA levels with frailty and all-cause mortality.Journal of molecular medicine (Berlin, Germany) · 2015Pooled it
- The association of the mitochondrial DNA OriB variant (16184-16193 polycytosine tract) with type 2 diabetes in Europid populations.Diabetologia · 2013Pooled it
- Type 2 diabetes mellitus duration and obesity alter the efficacy of autologously transplanted bone marrow-derived mesenchymal stem/stromal cells.Stem cells translational medicine · 2021Trial
- Mitochondrial DNA Haplogroups Influence Oxidative Stress Profiles and Susceptibility to Metabolic Syndrome in an Asian Population.Antioxidants (Basel, Switzerland) · 2026Article
- Associations between peripheral blood mitochondrial genomic variants and gestational diabetes mellitus and postpartum abnormal glucose metabolism.Journal of diabetes investigation · 2025Article
- The Potential Protective Role of Mitochondrial Haplogroup R in Ovarian Response: An Exploratory Study.International journal of molecular sciences · 2025Article
- Association of mitochondrial haplogroup H with reduced risk of type 2 Diabetes among Gulf Region Arabs.Frontiers in endocrinology · 2024Article
- Metabolic Syndrome and β-Oxidation of Long-Chain Fatty Acids in the Brain, Heart, and Kidney Mitochondria.International journal of molecular sciences · 2022Review
- Mitochondrial haplogroups have a better correlation to insulin requirement than nuclear genetic variants for type 2 diabetes mellitus in Taiwanese individuals.Journal of diabetes investigation · 2022Article
- Intergenomic and epistatic interactions control free radical mediated pancreatic β-cell damage.Frontiers in genetics · 2022Article
- Mitochondrial Population in Mouse Eosinophils: Ultrastructural Dynamics in Cell Differentiation and Inflammatory Diseases.Frontiers in cell and developmental biology · 2022Article
- Oxidative Stress Biomarkers and Mitochondrial DNA Copy Number Associated withAntioxidants (Basel, Switzerland) · 2021Article
- Article
- Mitochondrial Haplogroup Reveals the Genetic Basis of Diabetes Mellitus Type 2 Comorbidity in Psoriasis.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2021Article
- Ischemic Stroke Risk Associated with Mitochondrial Haplogroup F in the Asian Population.Cells · 2020Article
- The Causal Role of Mitochondrial Dynamics in Regulating Innate Immunity in Diabetes.Frontiers in endocrinology · 2020Article
- Mitochondrial DNA Haplogroup N9a Negatively Correlates with Incidence of Hepatocellular Carcinoma in Northern China.Molecular therapy. Nucleic acids · 2019Article
- Relationships Between Adipose Mitochondrial Function, Serum Adiponectin, and Insulin Resistance in Persons With HIV After 96 Weeks of Antiretroviral Therapy.Journal of acquired immune deficiency syndromes (1999) · 2019Article
- Mitochondrial dysfunction in type 2 diabetes mellitus: an organ-based analysis.American journal of physiology. Endocrinology and metabolism · 2019Review
- Contribution of Mitochondrial DNA Variation to Chronic Disease in East Asian Populations.Frontiers in molecular biosciences · 2019Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Both the coding and control regions of mitochondrial DNA (mtDNA) play roles in the generation of diabetes; however, no studies have thoroughly reported on the combined diabetogenic effects of variants in the two regions. We determined the mitochondrial haplogroup and the mtDNA sequence of the control region in 859 subjects with diabetes and 1,151 normoglycemic control subjects. Full-length mtDNA sequences were conducted in 40 subjects harboring specific diabetes-related haplogroups. Multivariate logistic regression analysis with adjustment for age, sex, and BMI revealed that subjects harboring the mitochondrial haplogroup B4 have significant association with diabetes (DM) (odds ratio [OR], 1.54 [95% CI 1.18-2.02]; P < 0.001), whereas subjects harboring D4 have borderline resistance against DM generation (0.68 [0.49-0.94]; P = 0.02). Upon further study, we identified an mtDNA composite group susceptible to DM generation consisting of a 10398A allele at the coding region and a polycytosine variant at nucleotide pair 16184-16193 of the control region, as well as a resistant group consisting of C5178A, A10398G, and T152C variants. The OR for susceptible group is 1.31 (95% CI 1.04-1.67; P = 0.024) and for the resistant group is 0.48 (0.31-0.75; P = 0.001). Our study found that mtDNA variants in the coding and control regions can have combined effects influencing diabetes generation.
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